Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"immune infiltration"”.
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… the distribution and compartmental effects of immune populations and the tissue architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… alterations. <br/>Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and methylation classes (MCs), and to elucidate the role of the TAMs in meningioma progression utilising a patient-derived 3D co-culture model.<br/>Methods: Multiplex …
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Age-associated alterations in head and neck cancer
… tumors, such as cellular senescence, reduced immune functions, and altered stromal composition. Despite these tissue modifying features and the largely elderly HNSCC patient population, most pre-clinical cancer models are comprised exclusively of young animals, a discrepancy that likely …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… of Wnt signalling is associated with decreased immune infiltration, commonly associated with low overall survival and progression free survival. Ovarian cancer is driven by mutations in TP53, BRCA1, and BRCA2, and is characterised by genomic instability leading to complex genomic alterations. In …
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Pan-Cancer Analysis of RNA Dysregulation, Somatic Mutations, and Matrix Stiffness using Bioinformatics Approaches
… matrix stiffness influences tumor complexity, immune infiltration, and extracellular matrix alterations. These findings provide a deeper understanding of the molecular and biophysical characteristics of tumors, identify novel somatic mutations, and offer insights into potential therapeutic …
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Quantitative mass spectrometry-based approaches for characterizing the immunopeptidome and tyrosine phosphoproteome in cancer
… identify activated signaling pathways and assess immune infiltration in colorectal cancer. I also demonstrate how small molecules alter the peptide major histocompatibility complex repertoire in melanoma, and report copies-per-cell estimates of select treatment-modulated antigens using targeted …
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Molecular Consequences of High Taz Expression In Gliomas
… We show that TAZ-high gliomas associate with immune infiltration and extracellular matrix genes, whereas TAZ-low gliomas associate with neuronal development genes. Furthermore, TAZ overexpression causes widespread epigenetic alterations in the cell, with consequent silencing of neuronal …
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Computational analysis of cell-cell communication in the tumor microenvironment
Cell-cell communication between malignant, immune, and stromal cells influences many aspects of in vivo tumor biology, including tumorigenesis, tumor progression, and therapeutic resistance. As a result, targeting receptor-ligand interactions, for instance with immune check-point inhibitors, can …
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Recapitulating Dynamic Disease States from In Vitro to In Vivo: The Pathophysiology of Cell Fusion in Breast Cancer Metastasis and New Model Systems of Intracranial Aneurysm
… of elastin and collagen structure, increased immune infiltration, heightened cell activation and aberrant blood flow (hemodynamic forces). Although IAs have been studied for decades there are still no definitive causes for aneurysm stability vs growth and ultimately rupture. This is likely due …
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Integrated Analysis of Molecular and Clinical Features in Melanoma Patients with Brain Metastases
… (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An improved understanding of the molecular and immune correlates of OS could provide insights into MBM patient outcomes and guide therapeutic development. Thus, we analyzed clinical features …
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Microglial succinate receptor 1 (SUCNR1) sustains chronic CNS inflammation
… SUCNR1 signalling in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. I found that SUCNR1 expression increases in the inflamed mouse CNS, where it is mostly expressed by myeloid cells in chronic inflammatory lesions. Post mortem single-molecule fluorescence in situ …
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Computational profiling of the tumour immune microenvironment
… cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and widely-used approach to …
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
… chemoradiation, and variable susceptibility to immune-based therapies. Despite their clinical relevance, representative immunocompetent models of recently defined RRD subgroups are lacking. These subgroups are identified by specific somatically acquired mutations, survival, and immunotherapy …
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Targeting toll-like receptor 4 related inflammation using small molecule, TAK-242, to attenuate inflammatory damage in pancreatitis and islet transplantation.
… a pattern recognition receptor found on various immune, endothelial, and epithelial cells, can respond to both endogenous and exogenous ligands resulting in enhanced cytokine and chemokine production as well as immune infiltration and activation. In this study, I have used TAK-242, a small …
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Mechanisms of cytosolic DNA sensing and neuroinflammation in ataxia-telangiectasia
… are implicated in recruitment of peripheral immune cells, it could be speculated that chronic STING-dependent chemokine production may exacerbate inflammation by promoting immune infiltration into the CNS. Overall, this work implicates microglial cytosolic DNA sensing as a driver of …
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The development of novel metabolic therapies for the treatment of glioblastoma
… between HK2 and chronic inflammation, immune infiltration, and angiogenesis in the glioblastoma tumour microenvironment. This sequencing data was also utilised to identify several ‘matching’ compounds that induce expression changes comparable to HK2 knockdown, which could be explored as …
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The role of ERK5 signalling in macrophage behaviour during wound healing
… highlighted a significant role of dysregulated immune cells in impaired wound healing. We aimed to investigate the role of a key immune cell in wound healing: macrophages and how a known regulator of macrophages in other contexts, ERK5, influences wound healing, using genetic and therapeutic …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
<p>Blockade of negative immune regulators for example CTLA-4, and PD-1/PD-L1 has proven to be a clinically effective strategy to enhance tumor specific immune responses. Recently discovered novel immunoglobulin superfamily ligand V-domain Ig suppressor of T-cell Activation (VISTA) is a new target …
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Somatic Mutations in Ageing and Degenerative Disease
… to driver mutations, clonal expansions, and immune infiltration. Using NanoSeq, we characterise the mutational processes in isolated synovial cell types. Finally we show the power of NanoSeq for high- throughput driver discovery and identify 15 genes under positive selection in the synovium. …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… contribute to the ability of PDAC to evade the immune system and its resistance to immunotherapies (IOT) and cytotoxic treatments, by generating extracellular adenosine (eAdo) as a consequence of the conversion of a molecule of ATP by enzymes called CD39 and CD73. The stimulation of the …
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