Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"immune infiltrates"”.
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
… to advance the knowledge of the medulloblastoma immune microenvironment. We did so by aiming to (1) develop more accurate, immune-competent animal models of MYC- or NMYC-amplified medulloblastoma, (2) testing a novel treatment that combines conventional chemotherapies with a cell cycle checkpoint …
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Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… evidence has increasingly shown that patient immune responses play a central role in prognosis. Overall, increased tumour infiltrating lymphocyte (TIL) counts are associated with better outcomes. However, the prognostic significance of TILs varies by TIL type, with CD8+ (cytotoxic T-cells) …
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… indicating the prognostic significance of immune cell abundance in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave …
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Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
… the distribution and compartmental effects of immune populations and the tissue architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative distribution of three key immune infiltrates was initially assessed in the SEARCH cohort (n=332); CD8+ cytotoxic …
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Chemoprevention of Familial Melanoma
… toxic to melanocytes and activating an immune response against distant pigment cells. Cytotoxic experiments reveal that similar to 4-TBP, MBEH induces specific melanocyte death. To compare death pathways initiated by 4-TBP and MBEH, classical apoptotic hallmarks were evaluated in treated …
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Clinical and Therapeutic Significance of Obesity In Melanoma
<p>While the FDA approval of targeted and immune therapies in metastatic melanoma (MM) have dramatically improved outcomes in this disease, <em>de novo</em> and/or acquired resistance can limit the clinical benefit of these agents. The IGF-1/PI3K/AKT pathway has been implicated in resistance to …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
… with higher proliferation and decreased immune infiltrate, with an increase in genomic instability and homologous recombination deficiency during treatment. The immune TME composition and activity mirrored response to treatment, with cytolytic activity and innate and adaptive immune …
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The Role of Mesenchymal Cells in the Regeneration of Salivary Gland Tissue
… to their salivary glands, caused by lesions of immune infiltrates into the tissue surrounding duct structures. Some patients present with extensive lesions that destroy any residual secretory acinar tissue, leading to hyposalivation. This damage, and reduced salivation, can lead to deleterious …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… transition (EMT), and cancer-related immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in tumour progression, prognosis, and response to therapy in TNBC. In this study, we aimed to …