Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"immune heterogeneity"”.
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Complex N-Glycosylation in Anti-Tumor Immunity
… panel of clonal cell lines that recapitulate the immune heterogeneity of PDAC, we found that knockout of Mgat5 led to a significant and replicable decrease in tumor growth. This occurred not only in immune hot, “T cell-inflamed” tumors, but also the immunosuppressive “non-T cell-inflamed” tumors. …
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Dissecting Drivers of Basal Immunity and Acute Responses to Viral Infection
<p>Heterogeneity in the human immune system can lead to limited vaccine efficacy, poor response to therapeutics, increased susceptibility to immune mediated diseases, and differential outcome to infection. Studies to date have suggested a role for biological, environmental, and genetic factors in …
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Exposure heterogeneity, host immunity and virulence evolution in a wild bird-bacterium system
Immunological heterogeneity is the norm in most free-living vertebrate populations, creating a diverse and challenging landscape for pathogens to replicate and transmit. This dissertation work sought to determine sources of immunological heterogeneity, as well as the consequences of this …