Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"immune dysfunction"”.
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Immune Dysfunction in Cystic Fibrosis
… environment of the lungs or innate to CF immune cells itself, leukocytes were isolated from peripheral blood and stimulated with LPS and compared to healthy donors. Our hypothesis is that there will be an increase in cytokine expression in blood leukocytes as well, with a further increase …
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SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION
… organ affected by early hyper-inflammatory immune response in septic patients. On the other hand, the septic insult induces immune dysfunction in later phases of sepsis which in turn increases susceptibility to infections. The aim of this thesis was to investigate early and late inflammatory …
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Mechanisms of Innate Immune Dysfunction During Mycobacterium tuberculosis and HIV Co-infection
… goal of this study is to characterize innate immune signaling responses of macrophages, which drive excessive inflammation during Mtb and HIV co-infection. We previously identified that synergistic inflammasome activation within macrophages, the cellular host of both Mtb and HIV, leads to a …
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Molecular Mechanisms of Promyelocyte Maturation: Implications for Immune Dysfunction in Type II Diabetes
The data in this thesis indicate one, that the removal of the tyrosine phosphatase CD45 enhances activation of protein kinase C delta (PKCdelta), and two, PKCdelta activity in conjunction with STAT6 regulate the expression of the co-stimulatory marker B7.2 (CD86) and three, the expression of CD86 …
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Chronic fatigue and immune dysfunction syndrome: its relationship to underlying emotional and psychological issues
… relationship between Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) and the presence of underlying psychological and emotional issues. An exploratory design with naturalistic methods of inquiry was utilized to investigate whether the presence, or absence, of these issues had any …
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Microbiota-host interactions and infection dynamics in critical illness.
… of secondary infections, largely attributed to immune dysfunction and impaired host defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a significant reduction in infection-free …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… to it daily. ATR has been associated with immune dysfunction as well as other human health risks. The mechanism by which ATR suppresses the immune system has not been defined. It is known that ATR is a phosphodiesterase inhibitor, which causes intracellular accumulation of cAMP. …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… to it daily. ATR has been associated with immune dysfunction as well as other human health risks. The mechanism by which ATR suppresses the immune system has not been defined. It is known that ATR is a phosphodiesterase inhibitor, which causes intracellular accumulation of cAMP. …
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Development of a Humanized Mouse Model to Understand M.tb and HIV/M.tb Co-infection
… understand how HIV induces defects in the host immune response to increase susceptibility to M.tb. The goal of these studies is to develop the humanized BLT mouse as a small animal model to study HIV/M.tb co-infection and identify mechanisms of HIV-mediated immune dysfunction that alter the …
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Cellular immune mechanisms of psychiatric disorders and the stress response
… have been associated with abnormalities in the immune system. As I summarise in my opening chapter (Chapter 1), evidence from human and animal studies suggests that the immune system may be implicated in the pathogenesis of these disorders, at least in a subset of patients. However, the direct …
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Structural and Biochemical Examination of Aberrant dsDNA Metabolism in TREX1-associated Autoimmunity
… to facilitate orderly cell death and prevent immune dysfunction. Mutations in the TREX1 gene at positions Asp–18 and Asp–200 lead to dominant autoimmune phenotypes associated with familial chilblain lupus and Aicardi–Goutieres syndrome. The TREX1 dimer localizes to the …
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Structural Studies of the Mammalian RNase H2 Heterotrimeric Complex
… of the RNase H2 complex cause the rare autoimmune disease Aicardi Giouteres Syndrome. We determined the structure of the mammalian RNase H2 complex to better understand the molecular mechanisms behind RNase H2 mediated immune dysfunction. The structure has several unique features including …
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Molecular Players in Lupus: Leads from Proteomic Screens
… Erythematosus is a multifactorial systemic autoimmune disorder marked by anti-nuclear antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, peripheral …
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The Nonenzymatic Modification of Proteins by Steroids and DNA by Reducing Sugars; In Vitro and In Vivo Studies
… to be present in elevated amounts in the autoimmune disease Systemic Lupus Erythematosus (SLE). Protein modification by this steroid might induce immune dysfunction by either hapten formation or by covalently modifying immunoregulatory proteins.</p>
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
Tumors evade immune system tumor-controlling functions. T cells critical to antitumor immunity are tolerogenic in tumor-burdened animals, and fail to lyse neoplastic cells. Our goal was to investigate the kinetics of immune dysfunction related to tumor-burdened host (TBH) memory T cell responses …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
Tumors induce immune dysfunction through the production of soluble factors that subvert macrophage (Mf) function to favor tumor growth. Previous studies suggested that tumor-induced immune cell dysfunction may be reversible through regimens that disrupt tumor cell suppressor mechanisms and …
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miR-10b Rescues Diabetes and GI Dysmotility Associated with a Leaky Gut
… pathogens. Mounting evidence has suggested gut immune dysfunction, impaired barrier function, and gut dysmotility play a key role in the development of metabolic disorders and disorders of gut-brain interactions (DGBIs). In reference to the Rome IV criteria, the most common DGBIs, include …
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Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… aging populations, exacerbated by age-associated immune dysfunction, or immunosenescence. This dissertation investigates the immune responses that contribute to protection against SARS-CoV-2 and how these responses become dysregulated with increasing age. Given the evidence of impaired antiviral …
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Understanding the Role of Mitochondria in Driving Antiviral Inflammatory Responses
Aging is associated with immune dysfunction and increased risk of morbidity and mortality due to infectious diseases, as exemplified by the COVID-19 pandemic. To improve health outcomes in these populations we need novel therapeutics that can restore immune function. Targeting macrophages is a …
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The Role of the IL-23/Th17/IL-17 Axis in the Pathophysiology of Endometriosis
… EM etiology and pathogenesis remain unclear, immune dysfunction is recognized to enable lesion establishment and progression. Notably, the IL-23/Th17/IL-17 axis is significantly altered in EM and associated with disease severity. This is notable as in other chronic inflammatory diseases, IL-23 …
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