Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"immune crosstalk"”.
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
… affects immunologic responses by a global immune system suppression, including dysregulation of cytokine mediators, leading to increased inflammation throughout all systems, termed inflammaging. However, understanding healthy aging mechanisms can bypass this effect. Inflammaging also leads …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… identified infection-dependent alterations in immune, vascular, and metabolic pathways, including epithelial cell apoptotic and viral processes. These findings indicate that systemic infection amplifies neuroinflammatory and endothelial signalling already perturbed in AD, potentially …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… and cytokine arrays to characterise fibroblast-immune crosstalk. I isolated Piezo1-WT and Piezo1-KO mouse cardiac fibroblasts, then performed mechanical stretch, whole-cell patch-clamp, and LC-MS/MS secretome analyses to define PIEZO1-dependent effects. I conducted a comprehensive investigation …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… It has become increasingly clear that peripheral immune cells infiltrate the brain parenchyma as part of the physiological response to tissue damage after HI injury. The interplay between infiltrating immune cells and brain resident cells during the inflammatory response is however dynamic and …
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Molecular Mechanisms of Sensing and Synergy by Anti-Bacteriophage Immune Systems in Staphylococcus
… across all domains of life have evolved immune strategies in the form of genetically encoded systems to defend themselves. Immunity can be conceptualized as occurring in three fundamental stages. First, the immune system must identify an invading pathogen— either directly via recognition …
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Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System
… surface in mammals and harbors the most numerous immune cell reservoir as well as a complex and autonomous nervous system. The GI tract is continuously exposed to foreign antigen and potentially toxic chemicals through the ingestion of food. In addition, the lumen of the human GI tract is …