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Showing 1 to 20 of 30 for “"immune complexes"”.
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Circulating immune complexes in acute rheumatic carditis
… has not yet been identified. Circulating immune complexes have previously been measured in some children with acute rheumatic fever. The normal or raised complement components measured by some workers in acute rheumatic fever suggests that the immune complexes may not be complement fixing. …
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Activation of Helper T Cells by Immune Complexes
Made available in DSpace on 2014-12-14T13:28:19Z (GMT). No. of bitstreams: 1 7913431.pdf: 3767142 bytes, checksum: fb9a97e5c018f0d12b03d1089470af50 (MD5) Previous issue date: 1978
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On the immunopathogenesis of systemic lupus erythematosus - Immune complexes, type I interferon system, complement system and platelets
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed …
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NZB/NZW F1-Derived Monoclonal Anti-Dna Autoantibodies: Dual-Specificity and Immune Complex Formation
The glomerulonephritis associated with the autoimmune disease Systemic Lupus Erythematosus (SLE) is mediated by immune complexes composed of DNA, complement components and anti-DNA autoantibodies, with the primary pathogenic antibodies being dsDNA specific. Recent studies had identified a …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
Innate immune recognition of extracellular host-derived self-DNA and self-RNA is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with …
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Studies of the idiotypic network through the use of a novel hemolytic plaque assay
… simultaneous presence of Ab1, so that Ab1-Ab2 immune complexes escape detection. In contrast, immune complexes should not complicate the enumeration of Ab2 producing lymphocytes in a hemolytic plaque assay. This study utilizes a procedure that allows detection of Ab2 producing cells in such an …
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Apoptotic Cells, Anti-Phospholipid Antibodies, and Anti-Chromatin Antibodies in Autoimmunity
… antibodies (APAs) are detected in various autoimmune diseases, such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects are not …
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Modelling the affinity maturation of B lymphocytes in the germinal centre
… centre reaction displace the antibodies on the immune complexes on the follicular dendritic cell. This feed-back drives the selection of high affinity centrocytes to be selected and become high affinity plasma blasts and memory B cells. This conclusion has been partially confirmed by recent …
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Monosialylgangliosides from human meconium: characterization using specific anti-oligosaccharide antibodies
… using nitrocellulose filters to collect immune-complexes. Radiolabeled oligosaccharide alditols which were recognized by specific antisera were affinity purified by eluting nitrocelIulose filters containing antibody-oligosaccharide complexes or using columns of immobilized …
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Engineering novel antibody-based molecules to probe the role of the immunoglobulin hinge and generate a potential cancer vaccine
… vaccines are designed to promote formation of immune complexes, which are preferentially taken up by dendritic cells via their FcRn receptors, with the aim of stimulating a strong anti-tumour immune response. Human MAGE-A2 fused to either human IgG1 Fc or mouse IgG2a Fc had been successfully …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… (SLE) is a chronic, multi-organ autoimmune disease characterized by the production of antibodies against self nuclear antigens. Genetics play a dominant role in disease pathogenesis and functional examination of spontaneously-arising lupus-prone animal models has provided key insights …
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Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
The role of autoimmunity and the loss of immune tolerance to own proteins have a significant place in the current ideas about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized by broad-spectrum organ manifestations, multiple autoantibodies and …
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THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION
… of FcRn itself will affect the IgG-associated immune responses. Although FcRn is expressed in a variety of tissues and cell types, the extent to which FcRn expression is regulated by immunological and inflammatory events remains unknown.I showed here that FcRn was up-regulated by the …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance to nuclear antigens. Hyperactive B cells are present in SLE patients and murine models of lupus, many of which have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. …
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Detection of staphylococcal enterotoxins in patients with rheumatoid arthritis or closed fracture
… and environmental factors. A T-cell immune response to the presence of PTSAgs in the joints of RA patients has previously been described. A link has been proposed between pathogenic micro-organisms and the development of chronic, autoimmune conditions. Potential pathogenic mechanisms …
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MicroRNA-mediated Attenuation of Inflammation in NZB/W Lupus Mice
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production and deposition of nuclear self-antigen-containing immune complexes. Epigenetic factors, including altered microRNA (miRNA) expression, may contribute to aberrant immune cell function in SLE. miRNAs are …
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Studies on the mechanism of human natural (NK) cell-mediated cytotoxicity (CMC): the role of lipoxygenation and arachidonic acid metabolites in NK-CMC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
… kidney MNP subsets at baseline and during autoimmune IgG immune complex (IC)-induced inflammation. We found that kidney MNPs could be divided into at least six subsets in healthy mice based on their expression of F4/80, CD11b and MHC II. These subsets differed in their localization within the …
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