Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"immune checkpoint blockers"”.
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… Death 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) immune checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, have shown that signaling by the PD-1/PD-L1 immune checkpoint may be bidirectional. Hence, we hypothesized …
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Reprogramming the Tumor Microenvironment in Desmoplastic Tumors to Potentiate Cancer Immunotherapy
… TME to overcome therapeutic resistance to immune checkpoint blockade (ICB), and developed an approach to identify predictive biomarkers of responsiveness to ICB. First, we developed a novel TME-activated polymeric material that can be conjugated with a class of anti-hypertensive drugs to …