Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"immune challenge"”.
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
The combined effects of maternal immune activation (MIA) and a second immune challenge later in life on pig behavior have not been studied. Deciphering these effects is particularly relevant in diseases that can have pronounced effects during gestation, such as porcine reproductive and respiratory …
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INTERACTIVE EFFECT OF DIETARY FIBRE AND IMMUNE CHALLENGE ON THREONINE REQUIREMENT AND INTESTINAL BARRIER FUNCTION IN GROWING PIGS
High dietary fibre (DF) and immune system stimulation (ISS) are thought to limit amino acid availability for protein deposition (PD) and growth in pigs. Fibre and threonine (Thr) may also play an important role in intestinal barrier function. Therefore, this thesis evaluated the independent and …
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Examining the Acute and Chronic Effects of Sepsis on the Circadian Clock in the Mouse
… relationships between the circadian and the immune systems, however while there is much evidence regarding the regulation of immune function by the circadian system, information regarding the impact of immune processes on the timekeeping system is more limited, including that regarding the …
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Effects of Heat Stress and Porcine Reproductive and Respiratory Syndrome Virus on Metabolism
Heat stress and immune challenge are costly issues to the swine industry causing significant loss in production and health including reduced efficiency in muscle accretion and energy utilization. Alterations to metabolism and immune response may participate in these shortcomings. The study …
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Understanding factors that affect gene co-regulation patterns
… of traits involved with behavior disorders and immune system can be complex and challenging. Gene expression and network analysis can help to elucidate the main molecules and pathways that influence complex traits. The goal of these studies is to understand factors that affect gene co-regulation …
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The Effects of Neonatal Immune System Activation with Lipopolysaccharide on Adolescent and Adult Anxiety Behaviours in Male and Female Rats
… of neonatal (postnatal days 3 and 5) acute immune system activation with lipopolysaccharide (LPS) on adolescent and adult anxiety behaviours. The major findings suggest that neonatal LPS does not have general long-lasting effects on adolescent anxiety and locomotor behaviours. Rather, early …
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Nasal Associated Lymphoid Tissue in health, infection and autoimmunity
The immune system exists in three core components - epithelial surface barrier immunity to prevent entry of foreign antigens from the environment; innate immunity to provide an immediate but non-specific cellular immune defence response to foreign antigens; and an adaptive immune response providing …
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Brain and Cognitive Consequences of Early-Life Immune System Challenge in a Songbird
… goal of this research was to determine whether immune system challenge during the critical song learning period in zebra finches (Taeniopygia guttata) would lead to long term negative impacts on song quality and learning, spatial learning, and neophobia. Immune challenge during this period of …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… for NDDs. To investigate this link, maternal immune activation (MIA) is often modeled using pathogen mimics, like poly I:C. While these models have provided invaluable mechanistic insights, poly I:C induces only a partial innate immune response, whereas replicating IAV elicits a complete …
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… of efficient mitochondrial translation during an immune challenge. Finally, I investigate mechanisms that could link mitochondrial translation to a loss of cytosolic protein synthesis, including mTOR signalling, mitochondrial reactive oxygen species generation and the integrated stress response. …
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Effects of dietary fermentable material on innate and adaptive immune measures in male and female rats under resting and immunized conditions
Sex-based differences in immune parameters are well recognized, and recent evidence suggests differences in microbiota composition between sexes, necessitating assessment of effects of dietary fermentable material (DFM) in both males and females. Effects of consumption of DFM of differing …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
Peripheral infection stimulates the innate immune system to produce pro-inflammatory cytokines, such as tumor-necrosis-factor-α, interleukin-1β, and interleukin-6, which signal through various communication pathways to induce a ‘mirror image’ of cytokine expression within the brain. Centrally, …
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Multiplexed immunoassay development for precision medicine diagnostics and protein characterization using silicon photonic microring resonators
… information-rich as those associated with the immune system. The immune system operates through a pathogen specific, biologically conserved response to coordinate detection and clearance. Immune cell associated signaling molecules, cytokines, modulate the immune response and their associated …
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The effects of 2’-fucosyllactose and Bifidobacterium longum subspecies infantis supplementation on growth, intestinal development and immune development and function in piglets
The newborn infant has a naïve immune system and immature gastrointestinal system. Breastfeeding is the optimal feeding mode to stimulate the development of these systems in the infant due to the bioactive nature of breastmilk. However, globally many infants rely on infant formula to meet their …
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Inflammatory Mechanisms And Vulnerability For Major Depression: From Animal Models To Drug Treatment
… suggest that the activation of the inflammatory/immune system contributes to the pathogenesis of depression. Indeed, depressed patients exhibit increased levels of inflammatory markers in both the periphery and the brain, and high comorbidity exists between major depression and diseases …
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Modulation of innate immunity by the cGMP signalling pathway in the drosophila malpighian tubule
The Drosophila innate immune system is one of the most widely characterised of all metozoan defense systems, and shares many similar characteristics to the innate immune systems of higher organisms. As such, Drosophila has become the model organism of choice for many researchers with regards to the …
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Understanding Osmoregulation and Immunity in Heteromyid Rodents Through Insights Gained from RNA-Seq
… expressed in spleen as an important tissue for immune response. Again I utilized the comparative framework of the Heteromyid family history in comparing the tropical <em>H. desmarestianus</em> to the temperate <em>D. spectabilis</em> and <em>C. baileyi</em>. My hypothesis was that greater …
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Effects of yeast products on immune response and intestinal health of dogs and mice
… modulating a few specific fecal microbiota and immune cell numbers, but little is known regarding the effects of yeast products on immune cell responsiveness, fecal microbiota profiles, and gut integrity. Herein, we aimed to test yeast products and hypothesized that they may provide health …