Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 784 for “"immune cells"”.
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Characterisation of TAPBPR in immune cells
… threats, such as virus-infected or malignant cells. This is aided by cell surface glycoproteins called the major histocompatibility complex (MHC). MHC class I (MHC-I) molecules are polymorphic structures that can display a large repertoire of peptides. Peptide loading occurs in the context of …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
… this pathway is also functionally relevant in NK cells, an innate lymphocyte, has not been fully established. Moreover, the unique adaptations in how Hh signalling is orchestrated in lymphocytes are not well explored. Specifically, it is not known whether lymphocytes process and palmitoylate their …
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Estrogen Modulation of Cardiac Immune Cells Is Cardioprotective.
… test the hypothesis that estrogen regulation of immune cells is cardioprotective. To accomplish this, male rats were supplemented with estrogen and subjected to the AV fistula. After 3 days post- fistula, genes expressed in the left ventricle were examined using a real time PCR array. A total of …
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Single-cell analyses of tumor-infiltrating immune cells
… a key problem due to the limited numbers of cells involved, and current methodologies that do not lend themselves well to the discovery of novel cell subpopulations. In this thesis, we investigate the use of various immunophenotypic and transcriptomic single-cell assays to characterize …
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Single-cell technologies for monitoring interactions between immune cells
Immune cells participate in dynamic cellular interactions that play a critical role in the defense against pathogens and the destruction of malignant cells. The vast heterogeneity of immune cells motivates the study of these interactions at the single-cell level. In this thesis, we present new …
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The Paradoxical Roles of Cell Death Pathways in Immune Cells
Cell death plays a vital role throughout the immune response, from the onset of inflammation to the elimination of primed T cells. Understanding the regulation of cell death within immune cells is of vital importance to understanding the immune system and developing therapies against various …
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Regulation of Wnt signalling in ovarian cancer and immune cells
… of Wnt signalling is associated with decreased immune infiltration, commonly associated with low overall survival and progression free survival. Ovarian cancer is driven by mutations in TP53, BRCA1, and BRCA2, and is characterised by genomic instability leading to complex genomic alterations. In …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… the intestine houses both the body's largest immune compartment, as well as a vast neuronal network, the enteric nervous system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of …
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Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… health status of their consumers. Modulation of immune responses is a plausible mechanism underlying these beneficial effects. The aim of this thesis was to investigate the effect of 33 Lactobacillus salivarius strains on the production of inflammatory cytokines from a variety of human and mouse …
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Innate Immune Cells may be Involved in Prepubertal Bovine Mammary Development
… this process is impacted by presence of innate immune cells. Whether or not such immune cells are present or involved in bovine mammary development is unknown. We studied the presence, location and changes in numbers of eosinophils, mast cells and macrophages in pre-pubertal bovine mammary …
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In vivo multi-modal imaging approaches for cancer, stem and immune cells
… imaging approach to track breast cancer cells in a safe, sensitive, and quantitative manner in vivo. We have subsequently optimized and applied our multi-modal system further to visualize mesenchymal stem cells (MSCs), a clinically-relevant cell type, with high sensitivity. Furthermore, …
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Host response to tuberculosis: impact of diabetes & cellular metabolism of immune cells
Contains fulltext : 178235.pdf (Publisher’s version ) (Open Access)
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The role of tissue-resident immune cells in PanIN to PDAC progression
… Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been described. In this thesis, I have characterised the role of …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… The adipose tissue contains a vast repertoire of immune cells, that under healthy conditions, facilitate the maintenance of metabolic homeostasis by coordinating tissue repair and remodeling, particularly in the transition from white adipose tissue to energy-burning beige adipose tissue. In this …
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Clinical Relevance of Immune Cells in Pancreatic Adenocarcinoma and their Implication in Immunotherapy
… have done during my PhD training, focused on the immune microenvironment of pancreatic adenocarcinoma (PDAC). The aim was to delineate key features of immunologic and tumour components shaping the biology of pancreatic cancer. Immunotherapy has been largely explored as a promising anticancer …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
… to simultaneously cause direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of oncolytic viruses, only limited attention has been paid to the interaction between viral therapy and the tumor …
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Gene expression profiling reveals novel actions of glucocorticoids on immune cells during inflammation
The innate immune response is triggered by bacterial activators such as lipopolysaccharide (LPS). This leads to production of mediators which co-ordinate the body's response to inflammation. In addition to the beneficial effects of such a response to LPS, this activation also accounts for the …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the current states the cells are in, but also to …
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Modulating effects of Fumonisin B1 and Ochratoxin A on immune cells in human carcinoma
Thesis (Doctor of Technology: Clinical Technology), Durban Institute of Technology, Durban, South Africa, 2005
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Engineering Lipid Nanoparticle-Mediated Delivery of Nucleic Acids to Lymphoid Organs and Immune Cells
… to degradation by nucleases and can induce immune responses when injected directly into the bloodstream. Moreover, due to their physicochemical properties, nucleic acids are unable to cross biological membranes to reach the cytosol or the nucleus. Viral and non-viral vectors are needed for …
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