Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"immune cell migration"”.
-
CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… receptor agonists in inflammatory/autoimmune and CNS injury models resulted in significant attenuation of clinical disease. The beneficial effects correlated with the observed reduction of inflammatory mediators and peripheral immune cell infiltration into the site of inflammation. …
-
Inverse opal hydrogel scaffolds as lymphoid microenvironments for the study of immune cell migration and immunotherapy
… of the body to destroy foreign or infected cells, by stimulating new or enhancing existing immune responses. One way to boost insufficient native immunity might be to engineer lymphoid tissue at disease sites (e.g., tumors). Such neotissues could be formed by attracting or transferring …
-
Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
Neutrophils are innate immune cells and the first to be recruited to sites of injury, where they are essential for host defence. Defective neutrophil recruitment can inhibit pathogen clearance, while impaired neutrophil resolution can lead to chronic inflammation. Therefore, it is essential that …
-
Controlling Curvature and Stiffness in Fibrous Environments Uncovers Force-Driven Processes and Phenotypes
… physical, genetic biology, biochemical, and immune cells to explore how the interplay with fiber networks can expand our understanding. We explored the physical interplay with biological processes of fibroblastic cells and show how these are critically regulated by forces that alter their …
-
An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection
The functional migration of immune cells during Leishmania infection is imperative for the activation of a protective immune response. In particular, migration of dendritic cells (DCs) towards the lymphatic vessel network and CCL19-producing lymph node is a key step in the induction of adaptive …
-
Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… an important role in activating multiple intracellular pathways, one of which is focal adhesion kinase (FAK). Phosphorylation of FAK can lead to the activation of various downstream signaling pathways that can increase tumor cell growth and proliferation, making it an ideal target for cancer …
-
Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
-
Roles of γδ T Cells in Influenza Infections and Methods for TCR Expression and Characterization
… extensive morbidity and mortality. Exuberant immune responses associated with immune cell migration/activation and cytokine/chemokine release, can be induced after infections. Recent studies have painted a complex picture of viral clearance and tissue repair in adults. The immune responses in …
-
The role of mosquito saliva on host immune response and pathogenesis of West Nile virus\r\n
… the potential effects of mosquito saliva on the immune system, it is important to re-evaluate the pathogenesis of these infections in the presence of mosquito saliva. A central question of this dissertation project was to determine if mosquito feeding or mosquito saliva could impact WNV disease. …
-
Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas
… fragmentation of tissue, resulting in liquefied acellular debris with histologically clear demarcated boundaries between treated and non-treated tissues. The acellular debris may include tumor antigens with preserved immunogenicity and the potential to generate systemic immune response against …