Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 157 for “"immune activation"”.
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Immune activation at the lung epithelial barrier
… In chapter 3 we have tried to understand the immune response developed towards antigens trapped in the lung vascular filter. We have shown that these antigens were presented to T cells by interstitial lung DCs in the mediastinal lymph nodes. In addition, we found that these interstitial lung …
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Dietary saponins and immune activation by eimeria species in broilers
Made available in DSpace on 2018-09-04T20:31:56Z (GMT). No. of bitstreams: 2 OELSCHLAGER-THESIS-2018.pdf: 920901 bytes, checksum: 5c35207f262e04634ec592c6474df117 (MD5) LICENSE.txt: 4213 bytes, checksum: cbb7ad70735d2b6fe407684270aa9e2f (MD5) Previous issue date: 2018-04-27
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
… However, an understanding of how the immune system responds to wireframe DNA nanostructures is currently lacking. Furthermore, it is unclear how controllable design parameters such as scaffold sequence, nanoparticle geometry, or ligand organization influence immune activation. In my …
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Exploring the effects of maternal immune activation on cisplatin-induced toxicities.
… that early-life stressors, like maternal immune activation (MIA) may contribute to these differences in susceptibility. As MIA has been associated with alterations in stress responsivity, inflammation, and metabolism, we wanted to determine if MIA would exacerbate cisplatin-induced fatigue …
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Unique gene expression profiles of microglia and astrocytes following innate immune activation
… neurological disease. Understanding how activation alters the transcriptome of these cells may offer valuable insight in regards to how activated cells mediate neurological damage. Furthermore, identifying common and unique pathways of gene expression during activation may provide new …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… treated by current antipsychotics. Maternal immune activation (MIA) during pregnancy, which can be triggered by a variety of infectious agents, has been associated with the development of schizophrenia in adult offspring. Epidemiological evidence indicates that elevated maternal levels of the …
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The impact of maternal immune activation on pig muscle development and postnatal immune function
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
The combined effects of maternal immune activation (MIA) and a second immune challenge later in life on pig behavior have not been studied. Deciphering these effects is particularly relevant in diseases that can have pronounced effects during gestation, such as porcine reproductive and respiratory …
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
Triple negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with poor prognosis and limited treatment options. Our group has previously identified a novel small molecule inhibitor, CHL-4, whose anti-tumour effects function through Lyn kinase, a member of the Src family …
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Role of a PTP1B Pathway in the Neuropsychiatric Expression of a Mouse Maternal Immune Activation Model
Activation of the immune system in gestating mothers has been identified as an important environmental risk factor for neuropsychiatric disorders. Maternal immune activation (MIA) animal models have been used to explore how the maternal immune system may cause expression of pathophysiology in …
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Effects of ARVs and HIV on mitochondrial function and immune activation in monocyte derived macrophages in vitro
… of accelerated aging and comorbidity. Macrophage activation drives persistent inflammation but the molecular mechanisms remain poorly understood. Uninfected and HIV-infected MDMs were treated with ARVs: TFV, 3TC, and EFV, and alterations in cell viability and mitochondrial function were …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
… brains, I investigated the effects of classical immune activation on circuit excitability and cell viability. To initiate inflammation, I administered lipopolysaccharide (LPS), an endotoxin derived from gramnegative bacteria, and interferon-gamma (IFNy), a cytokine typically released by …
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Characterizing the cellular latent reservoir of HIV-1 and the effect of immune activation on characteristics of the reservoir
… Overall, this thesis focuses on characterising immune activation and inflammation during the course of both untreated and treated HIV-1 infection in a cohort of South African women and subsequently determining whether clinical or immune measures influence characteristics of the latent reservoir …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… of temporal lobe epilepsy (TLE) and maternal immune activation (MIA). The kainic acid (KA) model of temporal lobe epilepsy (TLE) was used to induce Ammon’s-horn sclerosis (AHS) and to investigate behavioural and cytoarchitectural changes that occur in the amygdala related to Neuropeptide Y1 …
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Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples
… HIV infection or progression. The role of immune activation and chronic inflammation in the modulation of HIV acquisition risk and/or rate of HIV disease progression has been proposed as one of the most important mechanisms determining risk and pathogenesis but is not fully understood. A …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… therapy (ART) and are associated with chronic immune activation and oxidative stress within the systemic circulation and central nervous system (CNS). Pathological studies of post-mortem brain parenchyma indicate productive HIV replication in brain macrophages/microglia and restricted infection …
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A mouse model for the pathogenesis of immunodeficiency virus infection
… infection, which is characterized by progressive immune deficiency attributable to a slow but relentless depletion of CD4+ T cells, the main viral targets. HIV infection is also associated with increased T cell turnover and a state of generalized immune activation. One of the fundamental questions …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… the viral reservoir, leading to persistent immune activation and inflammation despite combination antiretroviral therapy (cART). While cART has transformed HIV into a manageable chronic condition, it remains unable to eradicate the virus or fully restore immune homeostasis. This study …
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