Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"immediate-early genes"”.
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Photic entrainment and induction of immediate-early genes within the rat circadian system
Immediate-early genes (IEG) are transiently expressed within the rodent circadian system in response to nocturnal light. Immediate-early genes are part of the mechanism by which light induces phase shifts of circadian rhythmicity. The two most studied light-induced IEG within the rodent circadian …
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Magnetic orientation in migratory birds
… von neuronalen Aktivitätsanalysen, basierend auf immediate early genes, nach Gehirnarealen, die während der Magnetkompassorientierung aktiv sind. Wir konnten Cluster N, eine Vorderhinrstruktur, identifizieren, die lediglich nachts bei Nachtziehern hohe, visuell vermittelte Aktivität aufweist, bei …
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Orientation in migratory birds: orientation mechanisms and their underlying neurobiological background
… of neuronal activity in the brain, visualized by immediate-early genes, lead to the identification of a forebrain area, named cluster N, which is specifically activated at night time in night-migratory birds but not in non-migratory control species during day or night. Further data show that …
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The Role of DNA Methylation in Addiction and Depression
… in regulating the mRNA expression of a number of immediate early genes—several of which are known to regulate dendritic spine morphology. Taken together, these data establish the importance of Dnmt3a in the NAc in regulating molecular, cellular, and behavioral plasticity to emotional stimuli.
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Profiling hotspots of DNA breaks and learning-induced gene expression in the mouse brain
… facilitating rapid transcriptional induction of immediate early genes (IEGs). However, the locations of these DSBs in vivo and their relation to brain function was unclear. In Chapter 2, following contextual fear conditioning (CFC) of wild type mice, we profiled the locations of DSBs genome-wide …
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Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli
The promoters of immediate early genes (IEGs) are rapidly activated in response to an external stimulus. These genes, also known as primary response genes, have been identified in a range of cell types, under diverse extracellular signals and using varying experimental protocols. Genomic dissection …
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
… of many neuron-correlated synaptic genes. Using single-nuclei RNA sequencing, I found global suppression of cell-cell signaling networks across all cell types, particularly involved in synaptic and growth factor signaling. Finally, using a novel postmortem fibroblast-derived induced …
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… prefrontal cortex to these processes using Immediate Early Genes (IEG) imaging. In addition, we investigated the mechanisms underlying neuronal activation by inhibiting ionotropic glutamate receptors (NMDA and AMPA) during or after spatial learning. We found novel evidence that the salience …
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A Multi-Region Analysis of the Acquisition, Consolidation and Retention of Spatial Memory in the Morris Water Maze using Immediate Early Gene Imaging
… for successful performance in this task. Immediate Early Genes (IEGs) have been implicated in learning and memory processes, and are used as markers of neural activity in a brain region in response to learning tasks. The use of adequate control conditions in these tasks has been identified …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
Immediate Early Genes (IEGs) are expressed upon re-entry of quiescent cells into the cell cycle following serum stimulation. These genes are involved in growth control and differentiation and hence their expression is tightly controlled. Many IEGs are regulated through Serum Response Elements …
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Towards dissecting neural ensembles : development of genetic profiling and targeting approaches
… expression levels of cell-type specific marker genes and compute complex Boolean logic to label these cells specifically. As a proof of principle, we demonstrate that the synthetic circuit achieves classification of two cell lines based on their gene expression profiles with high accuracy. …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… increase in NR4A1 expression, which triggered immediate early genes (IEGs) activating the ATF4-ATF3 stress response pathway. Notably, changes in serotonin dynamics, including increased levels and serotonylation, were observed, suggesting that serotonylation may regulate cellular stress …
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Role of the Human Cytomegalovirus IE2 Protein on Transcriptional Regulation of Viral Promoters
… by HCMV is dependent on expression of viral genes essential for replication. Immediate early (IE) gene products are the first subset of viral genes to be expressed during infection and function as key transcriptional regulators. IE2 is one the most predominantly expressed IE proteins and is …
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Delineating Mechanisms of Signal-Induced RNA Polymerase II-Transcription
… is a positive regulator of transcription of immediate early genes, a class of signal-induced genes that regulate diverse biological processes including cancer and development. Mechanistically, KAP1 negatively regulates elongation rate at the early stages of transcription, which allows for …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… Th2 cells are central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes …
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Investigations into DNA vaccination against Channel Catfish Virus
… vaccines, and immune response to vaccination. Genes were selected (ORFs 1 and 3 [immediate early genes], ORFs 6, 19, and 46 [membrane genes], and ORF59 [putative major envelope glycoprotein gene], cloned into a plasmid, and expressed in mammalian and fish cell culture to detect predicted …
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… and IV, we demonstrated that adipocyte-related immediate early genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, …
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Region-specific Mechanisms of Estrogen and Age on Neuronal Ensemble Activity During Spatial Navigation
… that take advantage of the kinetics of the immediate-early genes c-fos and Arc. Increased activation and plasticity during active exploration across several subregions of the hippocampus and striatum reflected similar inputs to these neural systems and similar effects of exploration. …
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The molecular, hormonal and symptomatic responses to hypoglycaemia in mice
… dataset, there was relatively low expression of immediate early genes (IEGs), which could evidence support for the successful minimisation of experimentally induced stress during the hyperinsulinaemic clamp technique. Numerous genes that were differentially expressed under hypoglycaemic or …
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Molecular and epigenetic mechanisms of fear memory
… is unknown how H3K4me3 is coordinated to target genes during memory formation. Monoubiquitination of histone H2B (H2Bubi) is critical for recruiting H3K4me3 to DNA in a gene-specific manner during memory formation in the hippocampus. Furthermore, there is a great overlap between H3K4me3 and …
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