Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"immediate-early gene"”.
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Dynamic Modulation of an Immediate -Early Gene in the Songbird Forebrain
"In the nervous system, immediate-early gene (IEG) induction is observed following exposure to salient events. Although the function of IEGs is not fully understood, one prominent model suggests that they are needed to consolidate memories of the inducing event---a ""feed-back"" model. However, a …
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Analysis of Immediate-Early Gene Expression in the Songbird Brain Following Song Presentation
… mechanisms are involved, the expression of an immediate-early gene (IEG) was studied. The isolation of the canary ZENK homologue is described, an IEG that encodes a zinc-finger protein and which is highly sensitive to growth factors and depolarizing stimulation, including stimuli leading to LTP …
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… prefrontal cortex to these processes using Immediate Early Genes (IEG) imaging. In addition, we investigated the mechanisms underlying neuronal activation by inhibiting ionotropic glutamate receptors (NMDA and AMPA) during or after spatial learning. We found novel evidence that the salience …
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Experience, neuroanatomical plasticity and expression of the immediate early gene ZENK in the visual cortex of weanling rats
This investigation combines anatomical and molecular approaches to determine if expression of a specific regulatory transcription factor correlates with morphological plasticity, using a model of experience-dependent plasticity.
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A Multi-Region Analysis of the Acquisition, Consolidation and Retention of Spatial Memory in the Morris Water Maze using Immediate Early Gene Imaging
… for successful performance in this task. Immediate Early Genes (IEGs) have been implicated in learning and memory processes, and are used as markers of neural activity in a brain region in response to learning tasks. The use of adequate control conditions in these tasks has been identified …
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Functional Analysis of the Human Cytomegalovirus Ul82 Gene Product PP71 Protein During Virus Replication
… recipients, and AIDS patients. The HCMV UL82 gene encodes for the tegument protein pp71. It has previously been shown that pp71 is required for efficient virus replication at low multiplicities of infection and that it is a regulator of immediate-early gene expression. However, the mechanism …
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Response Modulation by Single Units in the Auditory Neostriatum of Songbirds: Characterization of Responses and Their Relationships to Nuclear Gene Regulation in Adult and Juvenile Zebra Finches
"Presentation of birdsong activates immediate early gene (IEG) expression in the caudomedial neostriatum (NCM) of songbirds that are at least 30 days of age (d30) (Mello, et al., 1992; Jin & Clayton, 1997). However, when songbirds are raised in isolation, playback of birdsong fails to induce these …
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Central vasopressin signalling and aggressive behaviour
… behaviour in lactating rats. Patterns of immediate early gene expression during/subsequent to aggressive behaviour suggested specific neural circuits may have significant direct regulatory influence over particular behaviours, and that activation of the V1b vasopressin receptor, in these …
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Classification and Processing of Communication Calls in Little Brown Bats, Myotis Lucifugus
… of communication signals, using egr1 (an immediate early gene) as a molecular marker for brain activation. Three species-specific signals were included -- downward FM (DFM), courtship, and echolocation. Reversed DFM and silence groups were used as a comparison for basal activity. …
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Einfluss von vascular endothelial growth factor, transforming growth factor-beta-1, Interleukin-6, atrial natriuretic beptide, brain natriuretic peptide und Cortisol auf die Gen-Expression des menschlichen Herzmuskels in vitro
… des Myokards beteiligt sind, c-fos, einem immediate early gene, Calcineurin A, einer Calcium/Calmodulin abhängigen Phosphatase, die Ausgangspunkt eines Hypertrophie vermittelnden Signalweges ist, Glykoprotein 130 (gp 130), über welches einige Zytokine ihre Signale vermitteln, und …
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Stress and Growth Related Keratinocyte Pathways
… the cellular stress response is upregulation of immediate early genes that initiate and coordinate subsequent cellular events. IEX-1 is a novel immediate early gene that has been shown to be induced by gamma irradiation, phorbol ester treatment and ultraviolet irradiation. Goal of this thesis was …
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Deficient experience-dependent plasticity in the visual cortex of Arc null mice
… throughout development. With the advent of genetic mouse models it is now possible to probe the individual contributions of single molecules implicated in this process. The Arc (activity-regulated cytoskeletal associated) gene is an effector immediate early gene that has been suggested to …
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A Host Regulatory Circuit of HSV Gene Expression
… between productive and latent cycles, where the immediate-early protein ICP0 plays a critical role in driving lytic replication and reactivation from latency. During this complex process, HSV-1 triggers STING, a host factor that inhibits viral infection. It is well established that STING mediates …
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"""Copulatory memory"": A novel model for the study of recognition in the adult male rat"
… bulb (AOB) as evidenced by the activation of the immediate early gene c-fos in the granular cell layer of the male's AOB following interaction with a receptive female."
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Investigating Experience-Dependent Plasticity in the Accessory Olfactory Bulb
… such as mating, or whether it is a more general feature of the AOB circuit. Here, we describe a population of AOB internal granule cells (IGCs) that upregulate expression of the immediate early gene Arc following the resident-intruder paradigm in an AOS-dependent manner. Targeted …
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T lymphocyte responses to equid herpesviruses 1 and 4 in horses
… (EHV-1/Ab4) were shown to be antigen specific, genetically restricted and predominantly of the CD4' CD8+ phenotype. Cross-reactive CTL were induced in vitro with live EHV-4 virus, which killed EHV-1 infected blast cells. A proportion of EHV-1 induced CTL were shown to be directed against the …
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Murine Cytomegalovirus Encodes Proteins that Regulate Viral Late Transcription
… to virion structure, genome organization, gene expression, tissue tropism, and clinical manifestations. In my graduate studies, I discovered the function of two novel MCMV proteins during in vitro infection. I demonstrated that ORF M79 encoded protein pM79, and ORF M92 encoded protein pM92. …
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