Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"imatinib mesylate"”.
-
The study of the role of mast cells in malignant pleural effusion
… activation, respectively. cKIT inhibitor imatinib mesylate was effective against effusion development, indicating that mast cell-dependent effusion formation is actionable.
-
Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
… receptor tyrosine kinases KIT and PDGFR-α. Imatinib mesylate, a specific inhibitor of KIT and PDGFR-α signaling, delays progression of GIST, but is incapable of achieving cure. Thus, most patients who initially respond to imatinib therapy eventually experience tumor progression, and have …
-
Donor lymphocyte infusion after allogeneic stem cell transplantation in children
… with Philadelphia gene positive ALL survived by imatinib mesylate maintenance therapy although failure of DLI. Overall, 4 of 8patients were surviving and no patient died of GVHD and marrow aplasia. CONCLUSIONS: Our finding indicate that DLI after alloHSCT is well tolerated in sight of tolerable …
-
Expression and function of drug transporters in primitive CML cells
… BCR-ABL. The current first line of treatment is imatinib mesylate (IM), a tyrosine kinase inhibitor (TKI) that competes with ATP to block ABL kinase activity, which in turn prevents tyrosine phosphorylation of downstream molecules and selectively induces apoptosis of BCR-ABL cells. However, …
-
Patient Characteristics and Outcomes of Gastrointestinal Stromal Tumor Patients Undergoing Imatinib Plasma Level Testing
… stromal tumor (GIST) is effectively treated with imatinib, there are a number of clinical challenges in the optimal treatment of these patients. The plasma steady-state trough level of imatinib has been proposed to correlate with clinical outcome. Plasma imatinib level may be affected by a number …
-
The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… we utilized the tyrosine kinase inhibitor imatinib mesylate (IM), and demonstrated PDGF-PDGFRβ signaling pathway regulates Rb cell proliferation, invasion, and survival. We found increased PDGF-PDGFRβ signaling resulted in higher activity of the p53-inactivator, MDM2, as well as the …