Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"imaging agent"”.
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Micro- and millifluidic platforms for imaging agent synthesis
Molecular imaging, the non-invasive visualization of cellular and sub-cellular events, holds great promise to improve the basic understanding of biochemical processes and clinical diagnosis of diseases. One widely used molecular imaging technique is positron emission tomography (PET) that is …
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Selection and Evaluation of a Silver Nanoparticle Imaging Agent for Dual-Energy Mammography
… (CE) dual-energy (DE) x-ray breast imaging has emerged as an exciting, new modality to provide high quality anatomic and functional information of the breast. The combination of these data in a single imaging procedure represents a powerful tool for the detection and diagnosis of …
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Evaluation of F-18 Labeled Hydroxy Quinoline Derivative as a Potential PET Imaging Agent for Early Detection of Alzheimer’s Disease
… of AD is only possible post-mortem, non-invasive imaging has provided an important tool for early detection, and has helped in planning for an effective treatment. Targeted molecular imaging using positron emission tomography (PET) has provided the insight into understanding different disease …
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The stereoselective synthesis of iodinated analogues of reboxetine: new imaging agents for the noradrenaline transporter
… depression and Alzheimer’s disease. In vivo imaging of the noradrenaline transporter using single photon emission computed tomography has been hampered by the lack of a suitable imaging agent. The information from imaging studies could lead to a better understanding of transporter function …
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Bioinspired soft matter self-assembly and its use in biomedical applications
… culture platforms or nanocarriers for drug and imaging agent delivery, often consist mostly of soft matter. Despite advances in these fields, concerns still exist regarding the function, reproducibility, and cost of soft matter systems for biomedical applications. To mitigate these concerns, we …
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Fluorine-18-labeled estrogens, progestins and corticosteroids for receptor-based imaging of breast tumors and target areas of the brain
… 11$\beta$-ethyl 2 analogues of the breast tumor imaging agent, 16$\alpha$-($\sp{18}$F) fluoro-17$\beta$-estradiol (FES). Tissue distribution studies of 1 and 2 in immature female rats show high selectivity for target tissue (T, uterus) vs non-target (NT, muscle and lung), with T/NT ratios being …
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In vitro comparison of methylene diphosphonate radiopharmaceuticals
… tool and currently in widespread use as a gone imaging agent to delineate areas of altered osteogenesis. MDP is chelated with radioactive technetium-99m (Tc99m) and injected into the venous system of the body. It quickly clears from the bloodstream and is deposited into areas of bone …
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From conventional to microphotochemistry: A study of phthalimide and phthalonitrile derivatives
… such derivative was screened as a potential cell-imaging agent.
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… explore the synthesis and use of antibody-based imaging agents in preclinical models of cancer. This work can be described as two-fold. In the first part, we investigated how the use of a glycans-specific bioconjugation strategy affects Fc gamma RI binding and why it results in improved <em>in …
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… of [18F]-fluoride radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
<p>The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from …
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Scaffold Perception, ComPharmacophore Model Development, And Quantitative Structure-Affinity Relationships Of Sigma Site Ligands
… convulsive effects of drugs of abuse, and as an imaging agent for cancerous tissues, among others. Drug design efforts targeting these receptors have been hindered by a lack of structural information of the receptors themselves. Traditional ligand-based approaches have succeeded in generating …
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Hyperpolarized Carbon-13 Magnetic Resonance Measurements of Tissue Perfusion and Metabolism
<p>Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly …
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Image processing techniques in nuclear medicine
… <br></br><br></br>Hepatic perfusion imaging studies with <sup>99</sup>Tc<sup>m</sup>-tin colloid were performed in patients with primary colorectal carcimma. The hepatic perfusion index performed poorly in the detection of those patients with occult or overt hepatic metastastes, as …
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Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
… making it a very good target for cancer imaging and therapy. Using phage display technology, TF binding scFv fragments were selected from the McCafferty antibody library. The selected scFv clones were characterized in vitro for their TF specificity and cell binding properties by ELISA and …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
SPECT and PET are non-invasive imaging techniques in which radiotracers are used to study biochemical and physiological functions in the living brain. In vivo brain mapping with PET or SPECT can be of great importance in drug development as well as in the effective diagnosis, treatment and …
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Multimodality Somatostatin Analog For Fluorescence-Guided Surgery In Cancer
… tumors (NETs). Anatomical and functional imaging technologies are widely used during the pre- and postoperative stages, but intraoperative disease recognition relies on direct visual inspection and the hands of surgeons. The limited number of clinical tools for real-time intraoperative …
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Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
… for quantitative molecularly-targeted optical imaging of neoplasia. The first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection applications; this approach is demonstrated in freshly resected oral tissue. Most oral cancers are not detected until the …
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The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque.
… of this research study was the synthesis of an imaging agent, which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either legumain or MMP-2/9 were synthesized. This was …
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Polymer-coated iron oxide nanoparticles for medical imaging
… describes several formulations for in vivo imaging applications. The paramagnetic polymer-coated iron oxide nanoparticle aminoSPARK is used as a fluorescence-mediated tomography (FMT) imaging agent for stratification of prostate cancer tumors. This is achieved by conjugating it to a peptide …
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