Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"imaginal disc"”.
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Collective Behavior of Drosophila Melanogaster Neural Progenitor and Imaginal Disc Cells within Controlled Microenvironments
… from the developing brain lobes (DBL) to the Imaginal Disc (ID), through the OS, is a fundamental part of regenerative strategies in retina. Developmental signals governing retinal cell fate and migration have been well-studied using Drosophila Melanogaster. While conserved signaling pathways …
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Regulation of growth, patterning and cell fate-specification during imaginal disc regeneration in drosophila
… fate plasticity are regulated in regenerating imaginal discs. Regenerative growth must be carefully controlled and constrained to prevent overgrowth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. In …
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The role of cellular memory modules in the determination and transdetermination of Drosophila melanogaster imaginal disc cells
… expression of genes involved in patterning imaginal discs during larval development, which expression pattern may be modulated with time. The results demonstrate that expression of one of these genes, hedgehog, once activated, is maintained by a CMM even when the initial activator has …
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Notopleural Mutations Enhance Defects In Imaginal Disc Epithelial Morphogenesis And Macrochete Elongation Associated With Mutations in the Stubble-Stubbloid Locus
… actin cytoskeleton dynamics in developing imaginal discs through interactions with the Rho1 pathway. This work will discuss a genetic screen conducted to further investigate the role of Stubble in bristle and imaginal disc morphogenesis. From 50,000 EMS-mutagenized chromosomes 12 enhancers …
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The guardians of cell fate: protective mechanisms that ensure proper cell fate and patterning during imaginal disc regeneration in drosophila
… the late phases of regeneration in the wing imaginal disc of Drosophila. First, the identification of taranis as a regeneration-specific patterning gene and its subsequent characterization as a factor that is required to protect the regenerating cells in the wing imaginal disc from …
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Multiple axes of inter-organ signaling regulate organ scaling
… signaling, null mutants of babo result in small imaginal discs and small overall body size. This is in part due to metabolic defects caused by defects in Daw signaling. In this dissertation I report how Activin-β and Myoglianin regulate body size and organ growth respectively. In Chapter one, I …
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Mapping And Characterization Of 18-5 And 12-5, Genes Which Potentially Link The Rhoa Signaling Pathway To The Ecdysone Response
… understood. Morphogenesis of Drosophila leg imaginal disc epithelia is regulated both by the steroid hormone 20-hydroxyecdysone (ecdysone) and the RhoA GTPase signaling pathway. Recent evidence suggests that these pathways act cooperatively to control imaginal disc morphogenesis. Thus, leg …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
… in the developing limbs. In the Drosophila wing imaginal disc, there are at least two such organizing centers, located at the anterior/posterior (A/P) and dorsal/ventral (D/V) compartment boundaries. The genetic hierarchies which establish these organizers are starting to be understood, and it …
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Functional Characterization of a Cathepsin L in Drosophila Melanogaster
… that invasively grows toward and into the wing imaginal disc. The unfolding of Drosophila wing is a process following eclosion with a cuticular bilayer replacing epithelial cells originally packing the wing. We reasoned that protease functions might be needed for the invasion of ASP into the …
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Modeling human Usher syndrome during Drosophila melanogaster development
… morphogenesis in the follicular and wing imaginal disc epithelia. Cadherin Cad99C is a transmembrane protein with putative cell adhesion properties. Similar to its human ortholog Protocadherin 15, Drosophila Cad99C localizes to microvillar protrusions in the follicular epithelium. In this …
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Characterization of split ends function during Drosophila eye development
… wave of differentiation that passes through the imaginal disc eye primordium, Notch signaling is required for establishing and refining the expression of proneural Atonal (Ato). Ato promotes the EGFR pathway's reiterative signaling for progressive and sequential recruitment of cells within each …
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Genetic Analysis Of Rhoa Signaling During Epithelial Morphogenesis In Drosophila
… of the adult Drosophila leg from the leg imaginal disc precursor. Genetic analysis has identified several Drosophila genes involved in regulating cell shape changes during leg disc morphogenesis. These include members of the RhoA signaling pathway and the product of the Stubble-stubbloid …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
… localizes in the adherens junction in imaginal disc cells, whereas Sqh2P locates to the apical domain. Sqh1P and Sqh2P also show distinct patterns of expression in embryos. Sqh1P is expressed nearly ubiquitously and outlines cells consistent with a junctional localization, whereas Sqh2P …
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
… with Rho1 and Cdc42 during pupal eye and larval imaginal disc morphogenesis. First, clonal analysis in the post-mitotic Drosophila pupal eye epithelium demonstrated that Rho1 was required to maintain AJ integrity independent of its role in sustaining apical cell tension. Rho1 depletion disrupted …
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The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
… (SOP) cells during early stages of pupal eye imaginal disc morphogensis and also identities a Mid transcription factor network regulating eye development. Reducing the expression of <em>mid</em> transcripts within eye disc tissues using RNA interference (<em>mid-RNAi</em>) results in the loss …
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The nucleolar protein NOC1 is essential for ribosome biogenesis, and its reduction activates a novel MYC-p53 axis mediating nucleolar stress
… growth. Reduction of NOC1 in cells of the wing imaginal disc results in MYC upregulation, which drives nucleolar function but also promotes apoptosis. We also show for the first time a regulation between MYC and the transcription factor Xrp1, a master regulator of nucleolar stress and cell …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… ommatidia rotate 90° within the plain of the eye imaginal disc epithelium. Only a few mutations have been identified that disrupt this process and the signalling pathways regulating ommatidial rotation remain yet to be revealed. This study characterizes the argosroulette mutation, in which …
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The function of chromatin regulators during patterning and growth in Drosophila wing disc regeneration
… of tissue regeneration, focusing on Drosophila imaginal disc regeneration and the known functions of chromatin regulators during tissue regeneration in diverse model organisms. In Chapter II, I describe a genetic screen for chromatin regulators that are required for epithelial tissue …
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Functional and developmental characterisation of matrix binding sites in decapentaplegic
… expression of the variants in the wing imaginal disc caused overproliferation of the disc and expansion of the omb target gene expression. The extent of phenotypes correlated with the matrix binding ability of the variants. Corresponding disturbances of the wing vein pattern was observed …