Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"igf2bp1"”.
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… genetic variations of ARID5B and, more recently, IGF2BP1 that are associated with susceptibility to ALL. Genome-wide sequencing studies also discovered a new ALL subtype characterized of ZNF384-mediated chromosomal translocations, providing new insights into genetic heterogeneity in childhood ALL. …
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Dicer loss induces an oncogenic epigenetic switch in mesenchymal stem cells
… of greater than 50-fold of known oncofetal (Igf2bp1/2/3) genes, an effect much greater than that typically reported for miRNA-mRNA interactions. This suggests a requirement of let-7 for the continual suppression of mid-embryonic programs in adult cells. To investigate the regulation of these …
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Mechanisms of Induction and Maintenance of Constitutive Ptgs2 Expression in Colonic Mesenchymal Stem Cells
… of insulin growth factor 2 binding protein 1: Igf2bp1 or Imp1) results in a decrease in Ptgs2 and confirmed the ability of Imp1 protein and Ptgs2 mRNA to interact in the cellular environment. Additionally, we discovered increased Imp1 expression in the colonic biopsy wound bed compared to …
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Identification and characterization of a small molecule inhibitor of IMP-1 that decreases expression of IMP-1 target mRNAs and inhibits proliferation of IMP-1 positive cancer cells
… Growth Factor-2 mRNA-Binding Protein 1 (IGF2BP1/IMP-1/CRD-BP). IMP-1 exhibits an oncofetal pattern of expression, where it is expressed in embryonic development and its expression is repressed shortly after birth. However, the IMP-1 gene is reactivated in many different human cancers. …