Global ETD Search
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Showing 1 to 10 of 10 for “"identifiability analysis"”.
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A unified framework for identifiability analysis in bilinear inverse problems
… the question, we propose a unified framework for identifiability analysis in BIPs. We define identifiability of a BIP up to a group of transformations. Then we derive necessary and sufficient conditions for such identifiability, i.e., the conditions under which the solutions can be uniquely …
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Qualitative Adaptive Identification for Powertrain Systems. Powertrain Dynamic Modelling and Adaptive Identification Algorithms with Identifiability Analysis for Real-Time Monitoring and Detectability Assessment of Physical and Semi-Physical System Parameters
A complete chain of analysis and synthesis system identification tools for detectability assessment and adaptive identification of parameters with physical interpretation that can be found commonly in control-oriented powertrain models is presented. This research is motivated from the fact that …
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Parameter Identifiability and Estimation in Gene and Protein Interaction Networks
… models. In this paper, we present the results of identifiability analysis on a small test system, including the identifiability of parameters with respect to different measurements (proteins and mRNA), and propose a working definition for "biologically meaningful estimation". We also analyze the …
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Lifetime prediction for lithium-ion batteries undergoing fast charging protocols
… approach from the literature is extended with identifiability analysis to enhance fidelity of the inverse problem, the attribution of degradation modes, and the accuracy of parametric power-law lifetime predictions. Multiphase Porous Electrode Theory (MPET) is also explored in this thesis. In …
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Biological Circuit Design via BioCAD Tools
… and for local or global search; (ii) Sensitivity Analysis, for evaluating the importance of the parameters by ranking them according to their influence on the model; (iii) Robustness Analysis, for estimating the global and local fragility and robustness of optimal synthetic circuits; (iv) …
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The Potential Power of Dynamics in Epistasis Analysis
… classical approach to this problem is epistasis analysis. Broadly speaking, epistasis analysis infers the regulatory relationships between a pair of genes in a genetic pathway by considering the patterns of change in an observable trait resulting from single and double deletion of genes. More …
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A systems toxicology framework for improving the identification of paracetamol overdose
… probability of liver injury. In chapter 3, an identifiability analysis is performed on the PKPD model to identify parameter uncertainties. The model is also extended, enabling predictions for individuals deemed both “healthy” and “high-risk”. In 2017 I was awarded the in vitro toxicology …
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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science
… optimization, sensitivity, robustness and identifiability analysis, and are applied to a set of genome-scale models. Then, I augment the framework to predict metabolic adaptation to a changing environment. The adaptation of a microorganism to new environmental conditions involves shifts in …
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DEVELOPMENT OF PREDICTIVE MODELS FOR DIABETICS IN ROUTINE LIFE AND EMERGENCY SITUATIONS
The global healthcare systems have been in a transformation phase, moving away from a reactive to proactive approach of medical practices which rely more on engineering and technology. This transformation has not only been brought about due to improvements in measurement technology but also because …
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Dynamics of multiple populations interactions
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01