Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 139 for “"ibuprofen"”.
-
The effects of ibuprofen on exercise-induced muscle soreness and performance
1 PDF file (vi, 74 pages)
-
Solvent-induced modifications of the morphology and solid-state properties of ibuprofen
… crystal morphology and mechanical properties of ibuprofen was studied. Intermolecular potentials were calculated to assess the relative growth rates of crystal faces of ibuprofen. Comparison of the predicted morphology with solution-"grown crystals clarified the interaction of solvent with the …
-
Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… forms (MUDFs) of diclofenac sodium and S(+) ibuprofen have been prepared. Normal tabletting techniques were used to form the mini-matrices prior to their enclosure in hard gelatin capsules. Four natural hydrophilic gums, namely xanthan, karaya, locust bean and carrageenan gums as well as …
-
Beeinflussung der Proliferation und Vitalität humaner Chondrozyten durch Ibuprofen in Monolayer-Zellkulturen
… die Frage beantworten, ob die Verabreichung von Ibuprofen die Proliferation und die Vitalität der Chondrozyten verändert. Menschliche Knorpelproben wurden während Gelenkoperationen entnommen. Nach der Isolierung und Kryokonservierung, wie sie für die ACT verwendet wird, wurden die Zellen …
-
Genoprotective effect of aspirin and ibuprofen in human lymphocyte cells. Effect of nano and bulk forms of aspirin and ibuprofen on lymphocytes from breast cancer patients compared with those from healthy females
… size. This work aims to study the effect of both ibuprofen and aspirin on DNA damage using peripheral blood lymphocytes from breast cancer patients and comparing the results with those from healthy females as a control using the Comet and micronucleus assays. Western blot analysis (WBA) was used …
-
Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… to determine the acute and chronic effects of ibuprofen on rainbow trout (Oncorhynchus mykiss). Cyclooxygenase (COX) activity, vitellogenin (VTG) concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of trout to 1 and 10 mg/L in …
-
Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
… of preemptive and postoperative acetaminophen, ibuprofen, and placebo following orthodontic separator placement. Subjects were randomly assigned to 1 of 3 conditions: placebo, 650 mg acetaminophen, or 400 mg ibuprofen. The placebo or analgesic was taken 1 hour prior to separator placement and 6 …
-
Engineering Biomaterials using Quality by Design for the delivery of Ibuprofen for use in Cardiovascular therapy
… to overcome present limitations. In this thesis, Ibuprofen drug was loaded into two types of mesoporous silica (MCM-48 and MCM-41) via Electrohydrodynamic atomisation (EHDA). The Quality by Design (QBD) process was carried out prior to loading in order to identify optimum parameters (flow rate, …
-
Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
… and the inducible COX-2. Traditional NSAIDs like ibuprofen inhibit both isoforms with little selectivity while newer variants such as naproxen preferentially inhibit COX-2. Both COX isoforms share a high similarity between humans and fish creating a potential for off target effects to exposed …
-
METHOD DEVELOPMENT OF STANDARD DILUTION ANALYSIS ON MOLECULES AND DISSOLUTION STUDIES OF IBUPROFEN TABLETS ALONG WITH COMMON BEVERAGE CONSTITUENTS
… vivo</em> drug release. Dissolution testing on ibuprofen tablets alone and in the presence of ascorbic acid or caffeine was performed to mimic the administration using orange juice or caffeinated soft drinks to assess their impact on the dissolution rate of ibuprofen. Results using the external …
-
Synthesis and characterisation of new multi-component compounds containing the non-steroidal anti-inflammatory drugs fenbufen and S(+)-ibuprofen
Fenbufen and S-(+)-ibuprofen are non-steroidal anti-inflammatory drugs with poor aqueous solubility. In attempts to improve their solubility and bioavailability, crystal engineering techniques were employed to synthesise salts, co-crystals and cyclodextrin inclusion complexes containing these …
-
Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic solvents. Plain and ibuprofen-loaded binary and ternary nanoconjugates were …
-
The effect of speed of compression on the properties of compacts.
… to investigate the effects of compression on ibuprofen. Ibuprofen was found to consolidate mainly by plastic deformation with a lesser contribution from the melting of asperities. A significant amount of pressure induced melting and subsequent fusion bonding occurred at higher pressures. …
-
Production and characterization of composite nano/micro sized particles by rapid expansion of supercritical solutions (ress) co-precipitation
… (GC-MS) and by XRPD. Micronized composites of ibuprofen and bio-compatible polymer binders were produced by co-precipitation in rapid expansion of binary supercritical solutions (RESS). The binders used in this study are poly-L-lactic acid (PLLA), poly (lactic-co-glycolic acid) (PLGA), and …
-
Statistically Designed Spheronization and Scale-Up of Ibuprofen Microparticulates Using the Rotor Disk Fluid-Bed Technology: Coating for Prolonged Release and Hard Gelatin Encapsulation of Microparticulates
The aim was to develop uncoated and coated ibuprofen microparticulates in a one-step fluid-bed machine with rotor-disk insert, for immediate and prolonged drug delivery. Feasibilty studies using ibuprofen: Avicel (RC-581; 50:50), sodium lauryl sulfate (1%) as surfactant and water as binder in …
-
Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability
… graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot Melt Extrusion (HME) and extruded pellets obtained were used …
-
The effects of select non-steroidal anti-inflammatory drugs on green and brown hydra
… negative correlations were observed between ibuprofen, naproxen, diclofenac toxicity and select endpoints in Hydra. However, these correlations generally occurred in only 25% of the 7 day exposure toxicity tests performed. Thus, environmentally relevant concentrations of ibuprofen, naproxen, …
-
Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
… selection of excipients for a model drug ibuprofen. The predicted miscibility limits are verified with experimentally determined solubility limits. Dissolution experiments have been conducted to demonstrate the advantage of amorphous solid dispersions. This has been further extended by in …
Page 1 of 7