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Showing 1 to 20 of 157 for “"iPSC"”.

  1. Systematic Co-Culture of IPSC-CM and IPSC-AN Promote Co-Maturation In Vitro

    Terrell, William Gregory, Jr.

    … autonomic neuron differentiation efficiency (iPSC-ANs), establish a platform for CM/AN co-culture, and investigate the influence of these parameters on CM/AN crosstalk/responses.</p> <p>A protocol was developed in-house that incorporated <em>in vivo</em> developmental cues. The differentiated …

    binghamton Repository record

  2. Monte Carlo simulation of radiation transport for benchmarking Intel's iPSC/2, IPSC/860, and Touchstone Delta machine

    Klemas, Thomas J. (Thomas Jonas)Massachusetts Institute of Technology1994

    Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.

    mit Repository record

  3. Modelling neurodegenerative diseases in human iPSC-derived neurons

    Prestil, RyanUniversity of Cambridge2021

    … of in vitro disease models using human iPSC-derived neurons to provide a more accurate understanding of how disease mutations affect neuronal health. I first sought to model the polyglutamine disease spinal and bulbar muscular atrophy (SBMA), detailed in Chapter 4. Using iPSCs derived …

    cambridge Repository record

  4. DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.

    CAPPELLETTI, GIOIAUniversità degli Studi di Milano2024

    … neuronal models, including dopaminergic neurons, iPSC derived motor neurons, and human cortical organoids, in order to investigate this extremely current and concerning condition. Each of these projects, addressed below in the text, has independently contributed to broadening knowledge about the …

    milano Repository record

  5. Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids

    Schingo, Victor A.2025

    OBJECTIVE: Human induced pluripotent stem cell (hiPSC)-derived human intestinal organoids (HIOs) are increasingly utilized as in-vitro models for studying colorectal cancer (CRC). Prevalent oncogenic drivers in CRC include mutations in EGFR (L858R), KRAS (G12D) and CTNNB1 (S33C) which are known to …

    bu Repository record

  6. Phenotypic characterisation of human iPSC neuronal models of GM2 gangliosidoses

    Nicholson, AlexUniversity of Cambridge2025

    Gangliosides are crucial components on the outer leaflet of the plasma membrane of many cells, especially neurons. Their functions are broad and varied but their high abundance in neurons leaves these cells especially vulnerable to the effects of their accumulation in ganglioside lysosomal storage …

    cambridge Repository record

  7. EPIGENETIC REGULATION IN AN IPSC-NEURON MODEL OF FAMILIAL ALZHEIMER’S DISEASE

    Xu, Daniel2023

    … non-demented controls. In this thesis, I use iPSC-neurons derived from familial AD patients with an APP duplication as a model to study the functional effect of H3K27ac reduction. I found that in iPSC-neurons derived from the AD patients, homeostatic amyloid-reducing genes were upregulated …

    penn Repository record

  8. Cellular Phenotypes Associated with NRXN1 Mutations in Autism; an iPSC Study

    Massrali, AichaUniversity of Cambridge2021

    … derived from induced pluripotent stem cells (iPSC) using the OPTi-OX system to study the impact of NRXN1 mutations on excitatory glutamatergic neurons. I specifically study the molecular, morphological and functional changes caused by 1) induced mutations in CRISPR-edited cell lines; and 2) …

    cambridge Repository record

  9. Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons

    Patili, EleniUniversity of Cambridge2023

    Neuronal maturation is an intricate and tightly-controlled process in neurodevelopment, during which neuronal cells acquire their mature molecular, morphological and electrophysiological properties to function as the central components of the nervous system. However, the cell-intrinsic mechanisms …

    cambridge Repository record

  10. Investigating Parkinson’s Disease human iPSC-derived models through single-cell gene expression

    Patikas, NikolaosUniversity of Cambridge2022

    … use in research, induced pluripotent stem cell(iPSC) technologies are still under active development for clinical and disease modeling purposes. Directed differentiation protocols of iPSC to midbrain dopaminergic neurons enables the study human midbrain Dopamine(DA) neurons, the primary neuronal …

    cambridge Repository record

  11. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

    Samata, Bumpei京都大学 (Kyoto University)2017

    kyoto Repository record

  12. Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model

    McNamara, Madeline Elizabeth OdileUniversity of Cambridge2019

    … in the pathogenicity. Here, I use a patient iPSC-derived in vitro disease model that recapitulates the complexity of the patient abnormalities (Granata et al. 2017) to develop two potential therapeutic strategies (i) directly interfering at the level of the pathological mutation using an exon …

    cambridge Repository record

  13. MODELLING RIBOFLAVIN TRANSPORTER DEFICIENCY (RTD) USING IPSC-DERIVED MODELS TO TEST GENE THERAPY EFFICACY

    MEI, CECILIAUniversità degli Studi di Milano2025

    … of RTD patients-specific induced pluripotent (iPSC) line carrying several mutations in SLC52A2 gene. First, we tested gene replacement therapy on RTD type 2 patient-derived motoneurons using an adeno-associated viral vector 2/9 (AAV9) carrying the human codon optimized SLC52A2 cDNA. We …

    milano Repository record

  14. INDUCED PLURIPOTENT STEM CELLS (IPSC) TO STUDY PATHOMECHANISMS ASSOCIATED TO AMYOTROPHIC LATERAL SCLEROSIS (ALS)

    SANTANGELO, SERENAUniversità degli Studi di Milano2023

    … patient-derived induced pluripotent stem cells (iPSC) represents a great advancement to study neurodegenerative disorders, because iPSC maintain the individual genetic background and can be differentiated into different neuro- glial cell lineages, including motoneurons and cortical neurons. In my …

    milano Repository record

  15. Increased Oxidative Phosphorylation In An Ipsc- Derived Model of Rothmund-Thomson Syndrome Associated Osteosarcomagenesis

    Jewell, Brittany, <p>0000-0003-4483-5053</p>2022

    … of 12 induced pluripotent stem cell lines (iPSCs) from two paired RTS patient/ parental control (Family) sets. These iPSCs were validated, then differentiated to the bone precursor, mesenchymal stem cells (MSCs). After verification of the MSCs, we differentiated the MSCs to osteoblasts, …

    uthsc Repository record

  16. Development of a High-Throughput Human iPSC Chondrogenesis Platform and Applications for Arthritis Disease Modeling

    Adkar, Shaunak2019

    … of human induced pluripotent stem cells (hiPSCs) to prescribed cell fates enables the engineering of patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, disease modeling, and drug screening. In many cases, however, these differentiation …

    duke Repository record

  17. Creating CRISPR-Cas9 genome edited iPSC lines to model a patient-specific mutation in mitochondrial disease

    Jalkanen, NelliHelsingin yliopisto2020

    … editing in induced pluripotent stem cells (iPSC) provides an opportunity to model mt-aaRS mutations in vitro and investigate the effects of individual mutations on cellular phenotype. SARS2 encodes mitochondrial seryl tRNA-synthetase, and its c.1347 G>A mutation causes severe childhood-onset …

    helsinki Repository record

  18. Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome

    Lo, Yuanxi Motohiro FranklinUniversity of Cambridge2025

    … patient-derived induced pluripotent stem cells (iPSCs) carrying a heterozygous TGFBR1+/R487Q mutation and its mutation-corrected isogenic control iPSCs to model Type-I LDS. Phenotypic characterisation, such as by bulk RNA sequencing, revealed that LM-SMCs have abnormal phenotypes, including …

    cambridge Repository record

  19. Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons

    Schröder, Leonie FranziskaUniversität Bielefeld

    Neurodegenerative diseases are progressive disorders with age as the greatest risk factor. Parkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer’s disease. A stark increase in the incidence of neurodegenerative diseases is …

    bielefeld Repository record

  20. Ipsc Based Gene Correction and Disease Model of A New Class of Lgmd Due to Poglut1 Mutation

    Ortiz-Vitali, Jose, <p>https://orcid.org/0000-0002-6326-1529</p>2019

    … progenitors.</p> <p>To test this, we have used iPSCs for disease modeling and rescue experiments. Using a CRISPR based gene targeting method, we aimed to correct the point mutation and restore POGLUT1 function, thus restoring Notch signaling activity. Following correction, iPSC-derived gene …

    uthsc Repository record

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