Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"iNeurons"”.
-
Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… conversion into excitatory induced neurons (iNeurons) that are morphologically complex and electrophysiologically active after 2 weeks in culture. In addition, the inducible control of NGN2 expression from genomic safe harbour sites has provided a deterministic model system, enabling the …
-
Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
… induced human glutamatergic neurons (iNeurons) with astroglia from different brain regions. This work provided critical insights into the modulatory role of astroglia on BNI functionality, specifically how regional astroglia influenced neurite extension and branching in iNeurons, which …
-
The role of Synaptic Genes NRXN1 and SHANK3 in Autism: an induced pluripotent stem cell study
… The first hypothesis of this thesis is that iNeurons derived by NGN2 forward programming approach would express autism related genes, post synaptic density molecules, synaptic receptors and demonstrate mature electrophysiological activity relevant for studying autism related functional …
-
Investigating dynein-based transport of intracellular pathogens
… optimize a pipeline to study HSV-1 transport in iNeurons cultured in microfluidic devices.
-
Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
… in addition to glutamatergic neurons, our NGN2 iNeurons are made up of two additional types of neurons: cholinergic neurons with a visceral motor phenotype and neurons with a hybrid profile of cholinergic and glutamatergic transcription. Comparison with neurons co-cultured with glia found an …
-
THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… High-resolution phenotyping of human iNeurons and cortical brain organoids revealed convergent perturbations involving the autophagy pathways, synaptic programs, and cell-cycle control. While lysosome number was increased in both conditions, pH and enzymatic activity showed mirrored …