Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"iNOS"”.
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… regulation of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production, influences Th1 and Th17 responses in the Experimental Autoimmune Encephalomyelitis (EAE) model and in vitro T cell assays. Our results demonstrate that the absence of IFN-γ signaling exacerbates EAE severity …
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An investigation into Toxoplasma gondii infection and the expression of Arginase-1 and iNOS in human lung tissue
… of the immune modulating proteins Arginase-1 and iNOS in human lung biopsy samples. Previously, a 100% toxoplasmosis infection rate was found in 72 lung biopsy samples acquired from patients. This compared with 10% in healthy controls. Little is known of immune mechanisms acting on T. gondii …
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Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity
… from estrogen-treated mice also had upregulated iNOS mRNA, iNOS protein, and nitric oxide-regulated COX-2 protein when compared to control mice. Blocking co-stimulatory signals mediated through interactions of CD28 and B7 molecules by using CTLA-4Ig markedly decreased not only IFN-g, but also …
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Cardiovascular function in animal models of metabolic syndrome and type 2 diabetes : the role of inducible nitric oxide synthase (iNOS)
Activation of inducible nitric oxide synthase (iNOS) and oxidative stress have been shown to be associated with compromised cardiovascular function in streptozotocin (STZ)-induced type 1 diabetes. The aim of the project is to investigate cardiovascular abnormalities in a rat model of type 2 …
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Reacciones de cicloisomerización y alcoxiciclación de o-(Alquinil)estirenos y de 1,3-Dien-5-inos catalizadas por complejos de oro(I)
… se ha estudiado la reactividad de 1,3-dien-5-inos, sustratos estructuralmente relacionados con los o-(alquinil)estirenos, lo que ha permitido el desarrollo de una síntesis de bencenos y ciclopentadienos altamente funcionalizados. Estos últimos productos se han sintetizado también empleando …
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The relationship between nitric oxide synthase (NOS) and cyclooxygenase (COX) in the control of cervical ripening and parturition
… is to examine if there is relationship between iNOS and COX-2 in the control of cervical ripening and parturition. Cervices were obtained from estrus and timed pregnant Sprague-Dawley rats (n = 4-10 per group) under normal conditions; or after treating with LPS (100ƒÝg i.p.), Onapristone …
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Investigation of genetic and epigenetic mechanisms of iNOS gene expression in infection of natural populations of Apodemus sylvaticus with the parasite Toxoplasma gondii
… Laboratory studies have shown that the host gene iNOS influences sensitivity and resistance to T. gondii infection. This study sets out to investigate the role of genetic and epigenetic mechanisms of iNOS gene expression in the outcome of infection of natural populations of Apodemus sylvaticus …
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Der Einfluß von Steroiden und Medikamenten zur Behandlung der Multiplen Sklerose auf die LPS-induzierte iNOS/NO-Synthese in primärer Mikroglia neugeborener Ratten
… durch die induzierbare NO-Synthase (iNOS) gebildet. Die iNOS wurde bei MS-Patienten in Astrozyten und in Mikroglia nachgewiesen. <br>In der Modellerkrankung der MS, der Experimentellen Allergischen Enzephalomyelitis (EAE), wurde durch den Einsatz von iNOS-Inhibitoren eine …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… The mRNA and protein levels of IL-1β, TNF-α and iNOS were detected from 3 months, and they were increased with age. The mRNA and protein levels of IL-10 were detectable in 6 month-old transgenic mouse, which is 3 months later than the expression of pro-inflammatory mediators. Double …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this receptor is required to mediate iNOS expression, likely acting through the transcription factor nuclear factor kappa B …
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Investigating the relationship between lung cancer and the infection with the parasite Toxoplasma gondii
… and rats have demonstrated the involvement of iNOS and Arginase gene expression in T. gondii infection. Nothing is known about the role of iNOS and Arginase in human lung tissue infected with Toxoplasma. We have established and optimised an IHC protocol to detect iNOS and Arg-1 in lung cancer …
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Pathogenetische Bedeutung der induzierbaren Stickstoffmonoxid-Synthase für den akuten hyperoxischen Lungenschaden
… produziert durch die induzierbare NO-Synthase (iNOS), an der Pathogenese des hyperoxischen Lungenschadens beteiligt sein könnte. Ziel der Studie war es, die Beteiligung von NO an der Entstehung des akuten Lungenschadens unter Hyperoxie in vivo zu untersuchen. Dazu wurden unter standardisierten, …
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The Mechanism and Effects of TNF-α on Apoptosis in Auditory Cell Line
… states in the inner ear. Inducible NO synthase (iNOS) can be induced by cytokines and other inflammatory factors, and is generally thought to be associated with inflammation and other pathological processes in the cochlea. The purpose of the present study is to reveal that TNF-α could induce …
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Studies of fluorescent imaging for mRNA detection in living cells
… 2) Imaging of inducible nitric oxide synthase: iNOS) mRNA by strand-displacement activated Peptide Nucleic Acid: PNA) probes.: 3) Imaging of iNOS mRNA by binary fluorescently labeled PNA probes. The first approach was based on the work of our former lab member Dr. Huafeng Fang, who had …
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Inflammatory Mediators Associated with Pre-eclampsia
… Inflammation mediated molecules (NF-kB, p-JNK, iNOS, COX-2) were analyzed by Western blotting and RT-PCR. RESULTS AND CONCLUSION: First, Significant levels of macrophages were detected in both normal and patient groups. Second, Western blotting was also performed to analyze protein levels of …
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Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger regulatory factor 2 (NHERF2). We demonstrate that iNOS is overexpressed at or near the apical plasma …
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Μελέτη της ακτινικής δερματίτιδας σε ασθενείς με καρκίνο μαστού : συσχέτιση με κλινικές και παθολογοανατομικές παραμέτρους
… της έκφρασης των πρωτεϊνών Κi67, ATM, HIF-1a, iNOS και aGluc. Τα ευρήματα συσχετίστηκαν με την εκδήλωση της ακτινικής δερματίτιδας, λαμβάνοντας υπόψη το σωματικό βάρος και τον τύπο δέρματος (ταξινόμηση Fitzpatrick). Τα τελικά δεδομένα αξιολογήθηκαν περαιτέρω μέσω διαφόρων μονοπατιών και …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… of the inducible nitric oxide synthase (iNOS). AGE-induced enzyme activation and NO production could be blocked by intracellular-acting antioxidants: Ginkgo biloba special extract EGb 761, the estrogen derivative, 17ß-estradiol, R-(+)-thioctic acid, and a nitrone-based free radical trap, …
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