Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"iNKT cells"”.
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… opposite roles in CRC. Hyperactivation of immune cells can lead to chronic colitis and colitis-associated CRC, equally hyporesponsive immunity can promote disease progression, while anti-tumorigenic immunity efficiently limits tumor growth. Mucosal immunity is involved in the patrolling of …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
Invariant natural killer T (iNKT) cells constitute an important regulatory arm of the immune system. Defects in the number and activities of iNKT cells have been linked to the development of autoimmune diseases. The glycoprotein CD1d plays an integral part in the recognition and presentation of …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
<p>Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematopoietic malignancies achieving >50% complete response rates in numerous refractory/relapsed B cell malignancies. However, there are challenges that hinder CAR-T efficacy and bar the broader use of this therapy in …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… immuno-regulatory functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide a …
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
Invariant natural killer T (iNKT) cells comprise a unique subset of T lymphocytes that possess innate-like functional features and are primed for activation. iNKT cells exert robust anti-tumor cytotoxicity through both direct mechanisms and by modulation of other immune populations. However, the …
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… formation. It is secreted by various immune cells, including tissue-resident iNKT cells. In IBD, iNKT cells exhibit either pro-inflammatory or tolerogenic activities depending on the microbiota, raising questions about their role in CAC development. To investigate this, high-dimensional …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, …
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A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
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Characterisation of the immunomodulatory properties of human natural killer T cells
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
Alpha beta T cells express a T cell receptor (TCR) composed of an alpha beta heterodimer that is responsible for ligand recognition, which is associated with six invariant signaling chains, termed the CD3 subunits. These are organized into two independent signaling modules, the CD3 gamma epsilon / …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… including invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, which participate in early host defense against pathogens and tumors, remains poorly understood. In this thesis, I leveraged multiple established methods with which to induce psychological stress …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
Invariant NKT (iNKT) cells are a subset of T lymphocytes that express an invariant \(\alpha\) \(\beta\) T cell receptor (TCR) as well as an NK1.1 marker. They play an important role in autoimmune diseases, such as type I diabetes and lupus. In contrast to conventional CD4+ and CD8+ T lymphocytes …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. During the aftermath of pathogen clearance, a subset of effector T cells revert back to quiescence and differentiate into memory T cells. The Forkhead …
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
… to TB. Although it is well established that Th1 cells are crucial in the response against Mycobacterium tuberculosis (Mtb), Th1 cytokines may not be sufficient to control Mtb infection. A major focus of this thesis is the contribution of an understudied Th subset in Mtb immunity, namely Th22 …