Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"iNKT"”.
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… among which CRC. Invariant Natural Killer T (iNKT) cells are a lipid-specific, CD1d-restricted population of unconventional T cells residing also in the intestinal mucosa. Although their role in inflammation, infection and in tumor immune surveillance has been extensively elucidated, iNKT …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
… host disease (GvHD). Invariant natural killer T (iNKT) cells are an ideal candidate as they are restricted to the monomorphic CD1d protein in contrast to HLA restricted αβ-T cells and therefore are safe in the allogeneic setting. Furthermore, iNKT cells possess inherent antitumor mechanisms …
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A study of invariant NKT cell biology in health and disease
Invariant NKT cells (iNKT cells) have been increasingly recognised as an important cell type in regulating certain immune responses. Advances in the understanding of iNKT biology have provided opportunities for manipulating their functions for combating malignant, infective and autoimmune diseases. …
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Characterisation of the immunomodulatory properties of human natural killer T cells
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… immuno-regulatory functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide a …
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
Invariant natural killer T (iNKT) cells comprise a unique subset of T lymphocytes that possess innate-like functional features and are primed for activation. iNKT cells exert robust anti-tumor cytotoxicity through both direct mechanisms and by modulation of other immune populations. However, the …
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Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… for anti-microbial studies and to act as iNKT cell stimulatory ligands. Simple glycolipids, L-aspartic acid based glycolipids, glycoglycerolipids and L-serine based glycolipids were explored. Simple galactosyl glycolipids containing O- and N-glycosidic linkages and L-aspartic acid based …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… in ‘innate’ like lymphocytes; invariant NKT (iNKT) cells and intraepithelial lymphocytes (IEL).<br/><br/>Using the FOXO1-GFP knockin mouse, we studied T cell antigen receptor (TCR) control of FOXO1 nuclear localisation at a single cell resolution <i>in vitro</i>. We revealed that FOXO1 nuclear …
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TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS
… various immune cells, including tissue-resident iNKT cells. In IBD, iNKT cells exhibit either pro-inflammatory or tolerogenic activities depending on the microbiota, raising questions about their role in CAC development. To investigate this, high-dimensional single-cell cytometry, metagenomics, …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… including invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, which participate in early host defense against pathogens and tumors, remains poorly understood. In this thesis, I leveraged multiple established methods with which to induce psychological stress …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, they secrete cytokines according to the functional subtypes NKT1, NKT2, …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
Invariant natural killer T (iNKT) cells constitute an important regulatory arm of the immune system. Defects in the number and activities of iNKT cells have been linked to the development of autoimmune diseases. The glycoprotein CD1d plays an integral part in the recognition and presentation of …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
… T cells and invariant natural killer T (iNKT) cells. The mechanism by which these phosphorylations are regulated is not fully resolved. Herein, we report that p21 results from TCR interactions with MHC molecules prior to selection, supporting a model that the TCR has an inherent avidity …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
Invariant NKT (iNKT) cells are a subset of T lymphocytes that express an invariant \(\alpha\) \(\beta\) T cell receptor (TCR) as well as an NK1.1 marker. They play an important role in autoimmune diseases, such as type I diabetes and lupus. In contrast to conventional CD4+ and CD8+ T lymphocytes …
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Ontwikkeling van 2D en 3D Monte Carlo Algoritmes om Ionentransport te Simuleren in Isotrope en Anisotrope Media.
… vloeibaar kristalmedia en elektroforetische inkt. De nauwkeurigheid van het ontwikkelde algoritme wordt vergeleken met andere simulatiemodellen.
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Characterization of Mycobacterium tuberculosis-specific Th22 cells in HIV-TB co-infection
… to be conventional, rather than MAIT, γδ or iNKT cells. Indeed, analysis of the TCR clonality using vβ repertoire typing revealed similar repertoire usage between IL-22, IFN-γ-producing CD4+ T cells, and total CD4+ T cells. Overall, these data shed more light on the biology of IL-22-producing …
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MOLECULAR CHARACTERISATION OF EXPANDED MOUSE HAEMATOPOIETIC STEM CELLS USING A NOVEL IN VITRO REPORTER STRATEGY
Haematopoietic stem cells (HSCs) are responsible for the lifelong maintenance of the blood forming system which produces trillions of blood cells daily. They are able to achieve this because of two defining properties: 1) they can give rise to progeny which eventually form all of the blood cell …
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Unraveling Molecular Mechanisms Underlying the Development of Unconventional T Cells
The thymus supports and guides the generation of a diverse repertoire of mature T cells from precursors derived from the bone marrow. In addition to conventional CD4 and CD8 T cells, innate-like T cells also develop in the thymus and share features of the adaptive and the innate immune system. …