Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"iGluRs"”.
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) propionic acid (AMPA), and kainic acid (KA) receptors, and the fourth heterogeneous class is the metabotropic EAA receptor (mGluRs). It is now …
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Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). (RS)-2-amino-3-(3-hydroxy-5-methylisoxazole-4-yl) propionic acid (AMPA), and kainic acid (KA) receptors, and the fourth heterogeneous class is the metabotropic EAA receptor (mGluRs). It is now …
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Functional Analysis of Plant Glutamate Receptors
… of mammalian ionotropic glutamate receptors (iGluRs) and are hypothesized to be potential amino acid sensors in plants. Since their first discovery in 1998, the members of plant GLRs have been implicated in diverse processes such as C/N ratio sensing, root formation, pollen germination and …
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A general scaffold for the synthesis of cysiherbaine and its analogues
… effects on ionotropic glutamate receptors (iGluRs). iGluRs are essential components in the central nervous system (CNS); playing an important role in memory and learning. They also play a role in a number of neurological disorders, including schizophrenia, epilepsy, Rasmussen¡¯s encephalitis …
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Effects of Cocaine Sensitization on Drug Self-Administration, Mesocorticolimbic SAPAP Levels, and Prefrontal Ionotropic Glutamate Receptors
… and/or cocaine sensitization would alter iGluRs levels in the mPFC, and SAPAP levels in multiple sites of the mesocorticolimbic system. To test these hypotheses, we investigated the effects of psychostimulant sensitization on various parameters of self-administration by infusing a lowdose …
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Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
… subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, iGluRs are implicated in various neurological disorders, such as depression, schizophrenia, …
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ATGLR3.7 AS NEGATIVE REGULATOR OF ATGLR3.3 MEDIATED STRESS RESPONSES
… animals’ ionotropic glutamate receptor channels (iGluRs), which can form both homo and hetero-tetramer. This allows us to hypothesize that different assemblies of plant GLRs as well can bring to the formation of channels with different properties. Here we present multiple lines of evidence …
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Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
… delta family of ionotropic glutamate receptors (iGluRs) consists of glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) receptors. The function of GluD1 in the central nervous system (CNS) remains elusive. As a first step we conducted electrophysiological studies on the rat clone of GluD1 to …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… synapses, ionotropic glutamate receptors (iGluRs) respond to presynaptically released L-glutamate, the predominant excitatory neurotransmitter. Excitatory synaptic transmission is mediated primarily by AMPA-type glutamate receptors (AMPARs), and is crucial for the transfer and storage of …
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Investigation Of Whether Sedentary And Physically Active Conditions Lead To Altered Gabaergic Signaling In The Rvlm
… that 1) ionotropic glutamate receptors (iGluRs) contribute to increases in AP and SSNA in response to blockade of GABAA receptors and 2) SED conditions enhance glutamatergic excitation. Prior to microinjections in Inactin-anesthetized SED (n=6) and WR (n=5) rats, SAD was performed and one …
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
At synapses, the sites of communication between neurons, neurotransmitter is released from the presynaptic cell and binds to postsynaptic receptors on another. In the case of excitatory synapses, the predominant neurotransmitter, L-glutamate, binds to postsynaptic AMPA receptors (AMPARs). …