Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"i-Motif"”.
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Spectroscopic Analyses Of Factors Affecting Formation And Stability Of I-Motif Dna
The four-stranded i-motif (iM) conformation of DNA has importance to a variety of biochemical systems that include nanomaterials and oncogene regulation. Fundamental studies to understand iM formation and its structure in solution still remain to be done. In this dissertation, we will discuss the …
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Mechanical stability evaluation of i-motif and G-quadruplex structures under diverse circumstances
… conditions, another four-stranded structure, i-motif, is also formed in the strand complementary to the G-quadruplex forming sequence. Recent studies suggest gene regulatory roles for the i-motif structure as well. Although there is substantial understanding on the folding topology of …
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Investigating the Effect of Small Molecule Ligands and Cations on i-Motif DNA
… titration) and Colin MacDonald (for NMR on the i-motif). I would also like to thank Professor Rob Field for donating the compound library and Dr Andy Gates for donating the cations to be screened in chapter 4. Throughout this work I have been fortunate enough to learn a variety of different …
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Characterisation of DNA i-motif structures in the human genome and the role of non-canonical nucleic acid structures
… known DNA tetraplexes are G-quadruplexes and i-Motifs. G-quadruplexes rise from the interaction of four guanine bases and multiple tetrads stacked on top of each other, and i-Motifs rise from the intercalated interaction of cytosine base pairs, essentially binding four parts of a single strand …
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Theoretical And Experimental Studies Of Noncovalent Metal Cation Binding And Base Pairing Interactions Of Cytosine And Modified Cytosines
… that helps stabilize noncanonical DNA <i>i</i>-motif conformations, which are associated with Fragile X syndrome, the most widespread inherited cause of mental retardation in humans. Modifications of cytosine, such as methylation and halogenation, can influence the binding modes or the strength …
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Defining the Role of Secondary DNA Structures and Transcription Factors on the Transcriptional Control of the HIF-1alpha and VEGF Promoters
… DNA structures such as G-quadruplexes and i-motifs. We hypothesize that the i-motif and G-quadruplex structures can form within the pPu/pPy tracts of the HIF-1α and VEGF proximal promoters, which play important roles in the transcriptional regulation of these genes by acting as scaffolds for …
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Ruolo biologico delle conformazioni dei biopolimeri. Le porfirine come reporter specifici
… la loro capacità di adottare conformazioni i-motif. I nostri risultati forniscono approfondimenti sul ruolo delle strutture degli acidi nucleici nei sistemi biologici, offrendo possibilità di avanzamento nella diagnosi e nel trattamento delle malattie. Il lavoro futuro si concentrerà sulle …
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ALGORITMI DI GRAPH QUERYING PER LA RICERCA DI SOTTOSTRUTTURE IN GRANDI RETI BIOLOGICHE
… biologiche: nel primo sono stati ricercati i Motif, de niti secondo quanto descritto in (6), all'interno delle rete di regolazione della trascrizione di E. Coli 7.4; nel secondo 7.5 sono stati ricercati i complessi proteici di S. Cereavice all'interno della rete di interazione roteina-proteina …