Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"hypoxic tumor microenvironment"”.
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The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis
… du LPA joue un rôle important au cours de la tumorigenèse et du développement des métastases, les membres de cette voie étant souvent régulés à la hausse dans les cellules tumorales. La signalisation du LPA a également été impliquée dans la production de structures de dégradation, les …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… of the p53/Tag complexes and of DNA tumor virus transformation in general. It was generally believed that one of the major functions of Tag was to bind and inactivate the tumor suppressor p53. Our data, instead, support a model in which the Tag/p53 complexes are not inert, but rather …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
<p>Tumor growth often outpaces its vascularization, leading to development of a hypoxic tumor microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of …
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Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
… develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. To alleviate hypoxic and acidotic stress, cancer …
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The Role of Neuronal Pentraxin 1 in Promoting Pancreatic Cancer Progression
… in promoting cancer cell proliferating under a hypoxic tumor microenvironment. This proliferation advantage allows cancer cells to survive both in the primary tumor and promotes distal organ metastatic colonization. The final part of this study reveals NPTX1 to be clinically relevant in patient …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… hyperproliferation results in pro-oxidant tumor cell phenotypes. Thus, tumor cell antioxidant systems are often inherently strained and vulnerable to further oxidative attack. Targeted therapies can be designed to kill tumor cells by pushing them beyond redox thresholds compatible with …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor progression. Most …