Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"hypoxic stress"”.
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Hypoxic Stress Induced Gene Modulation in Medaka (Oryzias latipes) and Xiphophorus maculatus
Hypoxic zones in aquatic systems are becoming an increasing worldwide problem due to the stress these hypoxic zones place on economically important fishery resources. Evaluating gene modulation responses in fishes exposed to hypoxic conditions may provide the tools to better understand the …
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Regulation of the hif-1-dependent hypoxic stress response by C. elegans
… targets HIF-1 for proteasomal degradation. In hypoxic conditions, EGL-9 is unable to hydroxylate HIF-1; stabilized HIF-1 enters the nucleus to regulate the expression of target genes that coordinate the hypoxia response. Increased activity of HIF-1, produced by either hypoxia or an egl-9(lf) …
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The effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors on oxidative and hypoxic stress in the vascular endothelium
… cellular processes in the presence of oxidative stress and hypoxia. 3) To study the cellular response to these stresses in the presence of a statin. 4) To assess the effect of sudden withdrawal of statin on the endothelial cell proliferation and apoptosis.Statins exert a proliferative effect on …
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Physiological and Cellular Responses Used By Lake Whitfish (Coregonus Clupeaformis) in Response to Thermal and Hypoxic Stress at Different Points in Development
… change and even brief exposures to thermal or hypoxic stress can have detrimental effects. Fish may be able to respond to stress, using physiological and cellular mechanisms, to mitigate some of the damaging effects of stressor exposure and maintain homeostasis. I investigated the development …
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Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins
Antarctic icefishes (Family Channichthyidae) are unique in lacking the oxygen carrier hemoglobin (Hb) in their blood, leaving them with only 10% of the oxygen-carrying capacity observed in closely related red-blooded fishes. Previous studies have shown that icefishes have lower critical thermal …
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
… by a poorly perfused placenta hampered by hypoxic stress. Two stress-mediate angiogenic responses include post-transcriptional regulation of mRNA stability, and regulation of PML sequestering protein. We investigate whether these mechanisms occur in hypoxic stressed trophoblast and …
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The Proteomic Responses of Gill Tissue in Tidally and Subtidally-Acclimated Mussel Congeners (Mytilus trossulus and Mytilus galloprovincialis) to Acute Aerial-Emersion Hypoxia
… environments, making it one of the most stressful marine habitats. It is characterized by a 24 hr light: dark cycle and a 12.4 tidal ebb and flow that exposes animals inhabiting this habitat to a wide array of aerial-associated stressors such as changes in temperature, aerial exposure, …
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Dynamic contrast-Enhanced MRI of Pancreatic Islet Transplants
… immediately following transplantation leading to hypoxic stress on islets. The goal of our studies is to improve islet engraftment by monitoring and promoting the regrowth and maturation of new islet blood vessels in a clinically applicable manner. The developed technique is based on intravascular …
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Alternative mechanisms of translation initiation in modulation of gap junctional coupling
… the RNA binding protein IMP1 is sensitive to hypoxic stress and complexes with Gja1 mRNA, where it is necessary for alternative translation to generate GJA1-20k. We have demonstrated alterations in translation initiation of the Gja1 mRNA as a critical mechanism by which cells modulate Cx43 gap …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
… The aim of this thesis was to study the hypoxic regulation of polyamines and tumour cell-derived microvesicles (MVs), both of which have been associated with tumour development. It was initially demonstrated that epitope-specific interference of cell surface heparan sulphate proteoglycans …
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Egfr Modulates Microrna Maturation In Response to Hypoxia Through Phosphorylation of Argonaute2
… in regulatory roles to cope with a spectrum of stresses, such as hypoxia, which is frequently encountered in the poorly angiogenic core of a solid tumor. However, the upstream regulators of miRNA biogenesis machineries remain obscure, raising the question of how tumor cells efficiently …
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Impacts of Oil Exposure During Early Life Development Stages In Sheepshead Minnows (<i>Cyprinodon variegatus</i>) Under Different Environmental Factors
… prone to rapid fluctuations in environmental stressors such as oxygen concentration, and salinity. The consequence of combined exposure to crude oil and suboptimal environmental factors during early life stage development of fish is still largely unknown. The objective of this project was to …
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Analysis of axonal transport and molecular chaperones during neurodegeneration in drosophila
… locomotion defect after additional environmental stress. The cause of AT disruption and neuronal dysfunction in most cases of neurodegeneration is unknown, but it is associated with protein misfolding and aggregation that overrides cellular defences such as the heat shock protein (HSP) molecular …
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
… conditions such as acute respiratory distress syndrome and ventilator-associated lung injury. However, the effects of acute hypoxia on the diaphragm are largely unknown despite the potential clinical relevance. C57BL6/J mice were exposed to 8hr of hypoxia (FiO2 = 0.10) or normoxia. A …
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Electrochemical Focal Hypoxia for Cell Models
… vitro model to demonstrate that 10-minute focal hypoxic stress on the axons caused the induction of apoptosis in human cortical neurons, observed in the distant cell bodies.
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The Use of Computed Tomography to Measure Biogenic Structures in Recently Hypoxic and Normoxic Sediments on the Louisiana Continental Shelf
… the northern Gulf of Mexico vary in response to hypoxic stress, the seafloor on the continental shelf of Louisiana was analyzed during the spring and fall of 2009 at four provinces of similar sediment type that differ in recent history of bottom water oxygen concentration. Subcores were analyzed …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… we found a novel role of polyamines in the hypoxic stress response of cancer cells. The findings resulted in a strategy for enhancing the sensitivity of polyamine biosynthesis inhibition in experimental glioblastoma, i.e. highly aggressive brain tumors, through simultaneous anti-angiogenic …
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Programmed cell death, aerenchyma and pith cavity formation in vitro of Luffa cylindrica (L.) M. Roem.: an anatomical and physiological approach
… of lysigenous aerenchyma in the roots under hypoxic conditions. These characteristics are related to programmed cell death, which is a mechanism that is strictly related to plant growth and development and is therefore an important pathway for tissue differentiation, pathogen recognition, …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
… associates, our awareness of the significance of stress during gestation as a risk factor for heart diseases has expanded. We now know that events in utero can significantly alter gene expression patterns in heart tissue leading to increase susceptibility to ischemia reperfusion injury in …
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Hypoxia, Lipid Signalling and Tissue Metabolism in Obesity-Related Metabolic Disease
… this is a common signature of the obese and hypoxic liver. The obese liver retained some flexibility to alter metabolism in response to hypoxic exposure, showing a reduction in fatty acid metabolism, however mitochondrial capacity was unaltered in response to hypoxic stress in the obese …
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