Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"hypoxic ischaemic encephalopathy"”.
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MicroRNA expression and function in neonatal hypoxic ischaemic encephalopathy
Hypoxic ischaemic encephalopathy (HIE) is a devastating neonatal condition which affects 2-3 per 1000 infants annually. The current gold standard of treatment - induced hypothermia, has the ability to reduce neonatal mortality and improve neonatal morbidity. However, to be effective it needs to be …
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Mother-newborn EEG connectivity during affectionate touch and impact of hypoxic-ischaemic encephalopathy
… and with newborn neurophysiological responses. Hypoxic-ischaemic encephalopathy (HIE), a brain injury caused by lack of oxygen and blood flow to the brain, disrupts early neurodevelopment. I conducted a systematic review of HIE outcomes, and I found that HIE newborns are at increased risk of …
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Early prediction of hypoxic ischaemic encephalopathy in newborn infants in a resource-limited setting
Hypoxic ischaemic encephalopathy (HIE) after birth is an important cause of neonatal morbidity and mortality, particularly in resource-limited regions. Therapeutic hypothermia initiated within the first 6 hours of life, in settings that can offer neonatal intensive care, is a therapy that can …
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Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in sub-saharan africa: a scoping review
… therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE) in low- and middle-income countries. The aim of this review was to synthesize the literature describing TH for HIE in sub-Saharan Africa by searching Pubmed, Scopus, Google Scholar, and Web of Science from …
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The perceived barriers to timely therapeutic hypothermia treatment for neonates diagnosed with hypoxic-ischaemic encephalopathy when born outside the cooling facility within the private healthcare setting
Background Hypoxic-Ischemic Encephalopathy (HIE) is a debilitating neurological injury at birth due to a hypoxic event. The recommended treatment is therapeutic hypothermia (TH) provided at certain neonatal facilities and should commence within the treatment window of 6 hours (1). The outborn …
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Neurodevelopmental outcome of the high risk infant in Cape Town
… low birthweight and infants who have survived hypoxic ischaemic encephalopathy); to evaluate selected early neurodevelopmental assessments of these infants; and to propose a protocol for their effective follow-up. Three separate cohorts were selected and studied in order to achieve these aims. …
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Closing Research Gaps for Cerebral Palsy Prevention and Magnesium Sulphate Neuroprotection
… in late preterm or term neonates with hypoxic-ischaemic encephalopathy reduced CP risk (high-quality evidence), and prophylactic methylxanthines for endotracheal extubation in preterm neonates probably reduced CP risk (moderate-quality evidence). CP risk was probably increased …
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A descriptive study of suspected perinatal asphyxia at Mitchells Plain District Hospital. A case series
… Electroencephalograms (aEEG's) indicative of Hypoxic Ischaemic Encephalopathy (HIE) and four (13.8%) demised before day seven of life. Non-operative deliveries (p=0.005), lack of a doctor at the time of delivery (p=0.004) and neonatal chest compressions (p=0.044) were associated with abnormal …
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The influence of birth site on short-term outcomes of encephalopathic newborn infants treated with therapeutic hypothermia at Groote Schuur Hospital, Cape Town, South Africa
… or near-term newborns with moderate or severe hypoxic ischaemic encephalopathy (HIE) should be treated with induced hypothermia within 6 hours of birth, but many of the affected babies are born outside treatment centers. There are conflicting data describing the influence of birth site on …
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Study of the Term Neonatal Brain Injury with combined Diffuse Optical Tomography and Electroencephalography
… of neonatal term brain injury. With hypoxic ischaemic encephalopathy (HIE) and perinatal stroke being the most frequent contributors to brain injury in the term neonatal population, the first part of the thesis focuses on the description and ongoing requirement for their further …
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AI-based analysis of cerebral oxygenation in preterm and term infants
… hemorrhage (IVH) in preterm infants and hypoxic-ischemic encephalopathy (HIE) in term infants. Our findings demonstrated that features extracted from PRDs significantly outperformed traditional threshold-based approaches in predicting adverse outcomes, achieving an area under the receiver …