Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 508 for “"hypoxic"”.
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Hypoxic Incubation Chamber
… and testing of a novel controllable hypoxic incubator with fully functional oxygen gas control and temperature control in a humid environment. On the current market, a majority of the few hypoxic incubators use pre-mixed gas that does not offer precise control over gas concentration. …
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Angiotensin's Role in Hypoxic Injury
In order to determine the mechanism in which the AT2 receptor protected cortical neuronal cultures from sodium azide-induced apoptosis. We show that K+ channels are required for AT2 receptor neuroprotection and more specifically the actions of the delayed rectifier K+ channel. We suggest that the …
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DeadZone : inhabiting the hypoxic system
… growth in the average size and severity of its hypoxic zone and is one of the largest systems today. Where, 41% of the contiguous United States drains into the Mississippi basin releasing a tremendous amount of nitrogen and phosphorus into the coastal areas offering a nesting ground for massive …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates …
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Regulation of neutrophilic inflammation by hypoxic signalling pathways
… links exist between the pathways which regulate hypoxic and inflammatory responses. Our group has previously found that in mouse models of infection, acute hypoxia leads to increased sickness and that this is driven by neutrophilic inflammation. I have used a murine model of Lipopolysaccharide …
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Brain regeneration in a hypoxic-ischemic mouse model
… causes physical disability in human development. Hypoxic-ischemia (HI) is believed to account for a majority of cerebral palsy cases. During HI brain injury neurons, glia and endothelial cells are damaged and lose their function or die. But unexpectedly there are greater numbers of infants do not …
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STRATEGIES FOR REDUCING HYPOXIC INJURY TO THE BIOARTIFICAL PANCREAS
… investigated several approaches to preventing hypoxic injury to islets. First, we investigated the omental pouch as an alternative transplantation site for microencapsulated islets. Our studies demonstrated that the well-vascularized omental tissue supported long-term functionality of islets …
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MicroRNA expression and function in neonatal hypoxic ischaemic encephalopathy
Hypoxic ischaemic encephalopathy (HIE) is a devastating neonatal condition which affects 2-3 per 1000 infants annually. The current gold standard of treatment - induced hypothermia, has the ability to reduce neonatal mortality and improve neonatal morbidity. However, to be effective it needs to be …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… mechanisms underlying the spread of perinatal hypoxic-ischemic brain injury, particularly connexin hemichannels, pannexin channels and purinergic signaling, as well as to identify mechanisms of injury that are poorly attenuated by therapeutic hypothermia in order to find suitable additive …
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Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins.
… hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim of these studies was to examine the hypoxic response in small porcine …
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Cerebral metabolism of hypoxic fetal sheep investigated by NMR Spectroscopy
Contains fulltext : 146685.pdf (Publisher’s version ) (Open Access)
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Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer
Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts significant influence on their progression. Macrophages and neutrophils are major cellular components of innate immunity and contribute not only to O2 deprivation at the site of inflammation, but also …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… and the effect is also sustained at hypoxic conditions. Areas of low oxygen tensions, hypoxia, are a common characteristic in solid tumors and are associated with aggressive tumor behavior, treatment resistance and poor outcome in several tumor forms. In response to hypoxia, tumor …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… medial thicknesses, more in normoxic than hypoxic MCAs. ET-1-induced increase in arterial wall thickness is mediated by CaMKII and p38 dependent pathways in normoxic but not hypoxic arteries. Additionally, Myosin Light Chain Kinase (MLCK) and Smooth Muscle Alpha Actin (SMαA) colocalization …
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Early biomarkers to predict grade of encephalopathy following hypoxic ischaemic injury
The standard early markers for identifying and grading HIE severity, are not sufficient to ensure all children who would benefit from treatment are identified in a timely fashion. The aim of this thesis was to explore potential early biomarkers of HIE. Methods: To achieve this a cohort of infants …
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Effects of Intermittent Hypoxic Exposure on Physical Performance in Trained Basketball Players
… to support the use of a continuous (>8hr/day) hypoxic stimulus (either geographical altitude or simulated hypoxia) for enhancing the physical performance of endurance athletes. However, evidence supporting the use of acutely intermittent hypoxia (<1hr/day) for enhancing performance is less …
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Hypoxic Stress Induced Gene Modulation in Medaka (Oryzias latipes) and Xiphophorus maculatus
Hypoxic zones in aquatic systems are becoming an increasing worldwide problem due to the stress these hypoxic zones place on economically important fishery resources. Evaluating gene modulation responses in fishes exposed to hypoxic conditions may provide the tools to better understand the …
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Evaluating survival of the crayfish Orconectes nais exposed to hypoxic winter conditions
Call number: LD2668 .T4 BIOL 1987 K52
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Evaluating survival of the crayfish Orconectes nais exposed to hypoxic winter conditions
Call number: LD2668 .T4 BIOL 1987 K52
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