Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"hypoxia-ischemia"”.
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
<p>Hypoxia-ischemia (HI) occurs in 1-6/1000 live full-term births (Shankaran, 2009). Of those affected, 15-20% will die in the postnatal period, and 25% of survivors will be left with long-term neurological disabilities (Gunn, 2000; Vannucci, 1997; Fatemi, 2009). It has become increasingly clear …
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Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced edema
Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children. Although cerebral edema is a common outcome after HI, the mechanisms leading to the excessive fluid accumulation are poorly understood. Hyperoxia treatment after HI …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
<p>Neonatal hypoxia-ischemia (HI) represents an intractable clinical condition that lacks an effective treatment and results in blindness, cerebral palsy, and cognitive deficits. A primary mechanism of cell death induced by neonatal HI is mitochondrial dysfunction leading to metabolic crisis and …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
<p>Neonatal hypoxia-ischemia (HI) represents an intractable clinical condition that lacks an effective treatment and results in blindness, cerebral palsy, and cognitive deficits. A primary mechanism of cell death induced by neonatal HI is mitochondrial dysfunction leading to metabolic crisis and …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
IL-1 activity has been implicated in perinatal hypoxia/ischemia (HI) brain damage without the underlying mechanisms being characterized. We used a 7-day-old rat model to elucidate the role of NF-kB in HI stimulation of IL-1 signaling. HI was induced by permanent ligation of the left carotid artery …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… with ischemic brain injuries. Neonatal hypoxia-ischemia (HI) is a devastating perinatal event with a grim prognosis and limited therapeutic strategies. In recent studies, granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… with ischemic brain injuries. Neonatal hypoxia-ischemia (HI) is a devastating perinatal event with a grim prognosis and limited therapeutic strategies. In recent studies, granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor …
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in vitro models of hypoxia ischemia. However these studies hold limited clinical translations because the underlying mechanism remains unclear and the key …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
… studies using a rat model of adult global brain ischemia, IRL treatment attenuated cerebral injury resulting from hypoxia-ischemia in the neonatal rat. Thus, and perhaps most importantly, this work contributes to the development of a potential novel therapeutic approach in the management of brain …
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Capsinoids, Non-Pungent TRPV1 Agonists, Induce a Mild Hypothermia That Provides Short- and Long-Term Neuroprotection After Ischemic Stroke
… in instances of cardiac arrest and neonatal hypoxia/ischemia but faces different challenges in application to stroke due to the activation of cold defense mechanisms in conscious patients. This dissertation examines the efficacy and specificity of capsinoids (a purified mixture of capsiate …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… delayed response occurs and is characterized by hypoxia, ischemia, cerebral edema, and infection. During secondary brain injury, a series of neuroinflammatory events are triggered that can produce additional damage but may also help to protect nervous tissue from invading pathogens and help to …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… delayed response occurs and is characterized by hypoxia, ischemia, cerebral edema, and infection. During secondary brain injury, a series of neuroinflammatory events are triggered that can produce additional damage but may also help to protect nervous tissue from invading pathogens and help to …
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
… throughout the hippocampus following hypoxia-ischemia. Molecular and biochemical analysis of kainate- and sham-treated wild-type and GluK4 knockout hippocampal tissue revealed that GluK4 may act through the c-Jun N-terminal Kinase (JNK) pathway to regulate the molecular cascades that …
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Prenatal Undernutrition, Metyrapone, and the Cerebrovasculature
… On postnatal day 9-10, the rats then underwent Hypoxia-Ischemia (±) (unilateral carotid ligation combined with 1.5 hours 8% hypoxia after 24 hours). The goal of both studies was to determine whether glucocorticoids would increase ischemic vulnerability, an important marker of vascular health. …
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The Impact of Pomegranate on Memory Dysfunction after Cardiac Surgery
… with early postoperative dysfunction (i.e. hypoxia, ischemia).
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NNeMo (Neonatal NeuroMonitor) - a hybrid optical system to characterize perfusion and metabolism in the newborn brain
… was presented in a piglet model of neonatal hypoxia-ischemia. Clinical translation of NNeMo was demonstrated in PHVD infants during ventricular taps (i.e., CSF drainage). Changes in perfusion and metabolism are presented in premature infants at high risk of IVH within the first 72 hours of …
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The Early Events and Long-Term Effects of Perinatal Cerebral
Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Due to the increasing incidence of preterm and low birth weight infants and the lack of adequate treatment for HI, characterization of brain injury after HI remains an extremely relevant area of …
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Gene Delivery of Adenoviral-TMBIM6 Vector Protects the Neonatal Brain after Hypoxic-Ischemic Injury
<p>Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive …
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Perinatal hypoxic-ischemic brain injury – characterization, mechanisms and treatment
… such as Exendin-4. I showed that global cerebral ischemia was associated with a striking increase in concentration of adenosine triphosphate in the cerebrospinal fluid at 6 hours in near-term fetal sheep. Curiously, the increase in adenosine triphosphate occurred despite no change in the …
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