Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"hypoxia-inducible transcription factor"”.
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The role of HIF-1 alpha in the localization of embryonic stem cells with respect to hypoxia within teratomas
In embryonic stem (ES) cell tumors, the hypoxia-inducible transcription factor, HIF- 1[alpha], has been shown to be a tumor suppressor, and HIF-1[alpha]-expressing cells have been shown to localize preferentially in vivo to regions near tumor vasculature. These differences were proposed to be due …
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Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
… the need for identifying treatment predictive factors that can guide clinicians during treatment decisions. We have identified biomarkers that were associated with tamoxifen response in a material of premenopausal breast tumours. One of the markers is Pak1, a serine/threonine protein kinase, of …
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VHL inhibitors as chemical probes of the hypoxia signalling pathway
… (VHL) is the E3 ubiquitin ligase targeting hypoxia-inducible transcription factor-alpha (HIF α) for proteasomal degradation. The crucial function of VHL in response to hypoxia and cellular oxygen sensing are well established, owing to the use of genetic tools through knockout and knockdown …
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Decoding Lysine-11 Signals in Ubiquitination
… the functions of K11-chains I focused on the hypoxia inducible transcription factor (HIF) pathway, as K11-ubiquitination had been implicated in proteasome-independent degradation of the transcription factor. I established an in vitro assay to initiate HIF ubiquitination, via prolyl …
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The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis
… they bind and regulate the activity of growth factors and cytokines as well as cell migration and adhesion. The aim of this thesis was to investigate how hypoxia affects PG synthesis in macrophages and the potential consequences on the atherosclerotic process. We found that expression of two …