Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"hypoxia‐inducible factor (HIF)"”.
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the …
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DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery
… the DNA methylation program in the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… of oxygen sensing pathways including the Hypoxia Inducible Factor (HIF)-Vascular Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially novel VEGF-A splice variant with …
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A HIF-INDEPENDENT PROGRAM SUSTAINS TUMOR TREG FUNCTION IN OXYGEN-DEPRIVED ENVIRONMENTS
… and enriched with Treg. Their function in hypoxia has been poorly characterized. Definition of Treg responses to hypoxia would enable their selective targeting in cancer therapy, bypassing potential systemic adverse effects. We showed TME hypoxia and Treg infiltration correlated in a public …
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The Metabolic Transitions Regulated by the Estrogen-related Receptor (ERR) in Drosophila melanogaster
… mediating the metabolic transition induced by hypoxia and development. First, we investigate how dERR influences hypoxic adaptation in Drosophila melanogaster. We find that dERR is required for a competent hypoxic response alone, or together with hypoxia inducible factor (HIF), which is the …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… (CCRCC) is characterized by activation of the hypoxia inducible factor (HIF) pathway due to functional loss of the von Hippel-Lindau tumor suppressor gene. However, cooperating oncogenic events parallel to the HIF pathway remains poorly described. Our results presented here imply a …
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… Erythropoietin (EPO), a hematopoietic growth factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in vitro models of hypoxia ischemia. However these studies hold limited clinical translations because the …
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Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia
Hypoxia is a relevant physiological stress associated with many processes such as adaptation to high altitudes or human diseases (e.g. cancer). An essential component responsible to regulate the molecular response to hypoxia in the cell is the transcription factor called Hypoxia Inducible Factor …
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Systematic and local regulation of angiogenesis, and other adaptations, in response to hypoxia
… of many of these responses is a transcription factor (hypoxia-inducible factor, HIF). Among other responses it induces changes in erythropoiesis, glycolysis and angiogenesis. This study primarily aimed to elucidate the conditions of hypoxia, local or systemic, which would initiate capillary …
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Novel mechanisms for buffering the haemodynamic effects of dietary salt and the relevance of skin sodium in humans
… United Kingdom and it remains an important risk factor for cardiovascular morbidity and mortality. Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure (BP) response to salt intake. The mechanisms for this have not been fully explained, with renal …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… Given that epo is a target gene of the hypoxia inducible factor (HIF) pathway, we hypothesized that deletion of von Hippel Lindau (VHL), a negative regulator of this pathway, in the β cells would lead to enhanced transcription of HIF-target genes, which are largely pro-survival, and lead …
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TWEAK/Fn14 Pathway is Activated by Hypoxia and is a Novel Mediator of Retinal Neovascularization
… and retinopathy of permaturity. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor inducible 14 (Fn14), have been implicated in angiogenesis but their role in retinal diseases is largely unknown. The purpose of my study was to evaluate …
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Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway or key regulators such as histone demethylases (KDMs), that amplify HIF …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. Jumonji domain containing proteins demethylate tri- and dimethylated histone lysines and regulate chromatin structure. Substrate …
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Analyses of diverse stresses, including hypoxia, cyanide, and hypergravity in Caenorhabditis elegans
… of stresses including the response to cyanide, hypoxia, and hypergravity.</p> <p>Chapter 2 of this thesis focuses on understanding the mechanisms of cyanide resistance in C. elegans. We employed a novel microfluidic device to describe the resistance phenotypes with greater spatio-temporal …
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
The Hypoxia Inducible Factor (HIF) is a master regulator of the cellular response to hypoxia. Its levels and activity are controlled by dioxygenases called Prolyl-Hydroxylases and Factor Inhibiting HIF (FIH). In order to activate genes, HIF has to access sequences in DNA that are integrated in …
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The Mammalian Hypoxia Response Pathway: Regulation of HIF and HIF Prolyl Hydroxylases
Cells exposed to hypoxia -limited oxygen availability- initiate an adaptive response orchestrated by a transcription factor called Hypoxia Inducible Factor (HIF). HIF is composed of an oxygen-sensitive alpha -, and an oxygen-insensitive beta -subunit (ARNT). The stability and transcriptional …
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VALORIZATION OF CHESTNUT BY-PRODUCT FOR GASTROINTESTINAL HEALTH
… targets of inflammation, including the nuclear factor κB (NF-κB). A promising role as a further therapeutical target for gut disorders has been recently proposed for the regulatory subunit of hypoxia-inducible factor (HIF-1α), as a potential stabilizer of intestinal barrier integrity. Therefore, …
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Role of Chromatin Structure and JmjC Histone Demethylases in the Response to Hypoxia
In response to low oxygen (hypoxia), cells have evolved sophisticated gene expression programmes for survival and adaption. How the chromatin state coordinates these changes remains largely unknown. Global histone methylation changes occur in response to hypoxia, however, temporal dynamics of …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… conditions. Areas of low oxygen tensions, hypoxia, are a common characteristic in solid tumors and are associated with aggressive tumor behavior, treatment resistance and poor outcome in several tumor forms. In response to hypoxia, tumor cells induce a transcriptional shift which is mainly …
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