Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"hypothyroidism"”.
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
Thyroid hormones elicit many cellular and metabolic effects. Most of them are mediated by the thyroid hormone 3,5,3’-L-triiodothyronine (T3) nuclear receptors (THRs), which act as transcription factors. THRs have also been implicated in tumorigenesis, although it is unclear whether they act as …
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The Epidemiology and Management of Hypothyroidism in General Practice
Hypothyroidism is a common condition in general practice. Evidence of long-term outcomes and the effectiveness of treatment for subclinical hypothyroidism are lacking. This thesis provides new knowledge to support practice in relation to subclinical hypothyroidism. Methods and Results Several …
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The Effect of Hypothyroidism on Glucose Tolerance in Dogs
Background: Canine hypothyroidism is thought to cause abnormalities in glucose homeostasis, but the effect on glucose tolerance and insulin sensitivity has not been determined to date. Hypothesis/Objectives: The purpose of the study was to investigate whether hypothyroidism has an effect on glucose …
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The epidemiology of congenital hypothyroidism in the United Arab Emirates
The newborn screening for congenital hypothyroidism (CR) started in the West in the sixties. The guidelines for screening were introduced in the majority of western countries some 30 years ago and were adapted in 1997 by the World Health Organization. The United Arab Emirates (UAE) started newborn …
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Does thyroid sparing total laryngectomy decrease the risk of hypothyroidism?
… However, it is associated with a 32-89% risk of hypothyroidism, which represents a problem especially for patients without access to thyroid hormone monitoring and replacement. Sparing the thyroid gland does not compromise oncological control if thyroid lobectomy is reserved for intraoperative …
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The Relationship of Hypothyroidism and Reading Retardation in Elementary School Children
<p>The relationship between hypothyroidism and reading retardation was investigated among selected elementary school children for the purpose of contributing to data regarding the medical aspects of dyslexia in order to stimulate the interest of school health personnel. The experimental method was …
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The effects of induced hypothyroidism on the glucocorticoid stress response in Japanese quail (Coturnix japonica)
Many aspects of biological function are affected by hormones, from physiology to behavior, and the synthesis and release of hormones in vertebrates are regulated by the endocrine axes of control. A growing body of research shows that the mechanisms underlying the endocrine axes of control are …
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Effects of hypothyroidism on pancreatic islet development and tissue insulin signalling pathways in the ovine fetus
… of the project was to elucidate the effects of hypothyroidism on the growth and development of the sheep fetus in late gestation. Specifically, the project investigated the extent to which the changes in fetal growth induced by thyroid hormone deficiency were mediated by changes in pancreatic …
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The Effects of Prenatally Induced Hypothyroidism of the Neural Development and Problem Solving Ability of Maturing Hypothyroid Rats
The problem. The problem was to yield neonate rats hypothyroid by treating pregnant female rats with propylthiouracil (PTU), and then to evaluate the problem solving ability and the changes in the brain of the hypothyroid offspring. Procedure. Three 8-day sperm-positive female rats were given PTU …
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Effects of hyper- and hypothyroidism on serum FSH ad LH in gonadectomized and intact male and female rats
Thesis (M.S.)--Michigan State University. Dept. of Physiology, 1974
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The risk and severity of preeclampsia secondary to iodine deficiency and iodine deficiency-mediated subclinical hypothyroidism: mechanisms and early cardiovascular consequences
… cause of Subclinical (SCH) and overt (OH) hypothyroidism that are some of the risk factors of preeclampsia. Iodine deficiency in pregnancy, which can be corrected by supplementation, has been suggested in the past three decades as a risk factor for preeclampsia. It is uncertain if this is …
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DEFICIT DELLA FUNZIONE TIROIDEA IN GRAVIDANZA: STUDIO SU PREVALENZA, BENESSERE MATERNO-FETALE E VALUTAZIONE DELL'OPPORTUNITA DI UNO SCREENING
… pregnant women into five groups: 1) Overt hypothyroidism (OH); 2) Subclinical hypothyroidism (SCH); 3) Isolated hypothyroxinemia (IH); 4) Low TSH (isolated or associated with high fT4); and 5) Normal. A classification was made also according to the lower and upper ranges provided by the …
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Effects of ammonium perchlorate exposure on the thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos and post hatch chicks
… thyroid function and that the consequent hypothyroidism would alter the expression of thyroid sensitive genes. Laying Japanese quail hens were treated with 2000 mg/l and 4000 mg/l ammonium perchlorate in drinking water. Eggs from these hens were incubated. Embryos, exposed to perchlorate …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
… seizures and coma have been associated with hypothyroidism in dogs. Repeated studies have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research has also shown the development cerebrospinal fluid abnormalities in neurologically normal hypothyroid …
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Ancestralidade como fator de risco para hipotireoidismo: estudo da coorte ELSA-BRASIL
… Brazilian ancestral roots. The prevalence of hypothyroidism in Brazil is approximately 7.4% and has been highlighted as possibly one of the highest in the world. The ELSA-Brazil-thyroid study showed that women self-reported as white have a higher frequency of hypothyroidism than brown and …
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Levothyroxine Supplementation in Hypothyroid Bitches During Pregnancy
Hypothyroidism is the most common endocrine disease in dogs and has been shown to have a hereditary nature in many breeds. Previous studies have documented decreased fertility in bitches with experimentally-induced hypothyroidism, decreased viability at birth, increased periparturient mortality, …
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Functional Characterization of the C-terminal Cholinesterase-Like (ChEL) Domain of the Thyroid Hormone Precursor Protein
… (AChE). Mutations in Tg cause congenital hypothyroidism, the most common congenital endocrinopathy affecting 1 in 2,000-4,000 newborns, with a varying degree of phenotypic manifestations. Tg protein, regulated by TSH, is secreted to the lumen of thyroid follicles, where thyroxine …
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The clinical characteristics, presentation, and treatment outcomes of prolactinomas at Groote Schuur Hospital
… 73.1% (n=19) being most common, followed by hypothyroidism 53.8% (n=14) and hypoadrenalism 30% (n=8). Over 50% of patients with a giant adenoma had panhypopituitarism with hypogonadism in 100%, hypothyroidism in 77.8% (n=7) and hypoadrenalism in 66.7% (n=6). Hormonal deficiencies in the …
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The impact of diabetes on cardiac remodelling after myocardial infarction: potential role of thyroid hormone signalling
… (SHAM). The results show that AMI in tissue hypothyroidism caused significant down-regulation of TH receptors, TRα1 and TRβ1, in the diabetic myocardium without changes in T3, T4 levels in plasma. This response was associated with increased expression of β-MHC and distinct changes in cardiac …
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Central disorders of thyroid function: clinical, radiological and genetic phenotyping
… the TRHR gene giving rise to central congenital hypothyroidism (CCH) are presented. In the first chapter, an overview of central disorders of thyroid function are discussed with emphasis on TSHomas and congenital central hypothyroidism. Pituitary imaging modalities are also discussed with …
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