Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"hypothyroid"”.
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Levothyroxine Supplementation in Hypothyroid Bitches During Pregnancy
Hypothyroidism is the most common endocrine disease in dogs and has been shown to have a hereditary nature in many breeds. Previous studies have documented decreased fertility in bitches with experimentally-induced hypothyroidism, decreased viability at birth, increased periparturient mortality, …
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Alterations in cerebellar protein synthesis in propylthiouracil-induced hypothyroid rats
… and found to be significantly reduced in the hypothyroid state. The development of cerebellar cortical strata and cellular morphology was altered by prenatal, as well as postnatal PTU administration. To establish cerebellar synthesis of apo E and T1, total RNA was extracted, poly A RNA …
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Morphological imaging of the canine thyroid gland with an application towards hypothyroid dogs
… werden echografisch waargenomen in een populatie hypothyroIde honden: hypoechogeen en heterogeen parenchym, onregelmatige aflijning van het kapsel, ronde vorm van de schildklierlob op dwarsdoorsnede en verkleind schildklier volume. De vijf parameters gecombineerd, resulteerde in een sensitiviteit …
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The Effects of Prenatally Induced Hypothyroidism of the Neural Development and Problem Solving Ability of Maturing Hypothyroid Rats
… problem. The problem was to yield neonate rats hypothyroid by treating pregnant female rats with propylthiouracil (PTU), and then to evaluate the problem solving ability and the changes in the brain of the hypothyroid offspring. Procedure. Three 8-day sperm-positive female rats were given PTU …
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The effect of thyroxine on protein biosynthesis and ribonucleic acid metabolism in the rat
… cell-free Liver systems from treated normal and hypothyroid rats. However, the in vitro addition of the hormone only had a stimulatory effect, though quite erratic in magnitude, on the normal system. This difference in response has not been explained. The hypothyroid rat was also characterized by …
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Evaluation of cerebrospinal fluid biomarkers of endothelial damage and basement membrane degradation as indirect indicators of blood-brain barrier dysfunction in chronic canine hypothyroidism
… seizures and coma have been associated with hypothyroidism in dogs. Repeated studies have shown that there is loss of blood brain barrier (BBB) integrity in these animals. Current research has also shown the development cerebrospinal fluid abnormalities in neurologically normal hypothyroid …
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Developmental influences of thyroid hormones on the rat olfactory receptor sheet
… on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure olfactory neuronal proliferation and maturation.
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Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
We propose that decreased neural growth in hypothyroid animals and the robust rate of recovery is mediated by interactions of thyroid hormones with neurotrophins. We have found that hypothyroidism results in decreased hippocampal NGF levels, while up-regulating its receptors: the p75 neurotrophin …
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Α-ΦΕΤΟΠΡΩΤΕΙΝΗ ΚΑΙ ΣΥΓΓΕΝΗΣ ΥΠΟΘΥΡΕΟΕΙΔΙΣΜΟΣ
… SPOTS TAKEN BY HEEL PRICK FROM525 NORMAL, 77 HYPOTHYROID AND 213 TRANSIENT HYPERTHYROTROPINAEMIC (TH) NEONATES. THE BLOOD SPOTS WERE COLLECTED AT THE TIME THE NEONATES WERE DISCHARGED FROM THE MATERNITY UNIT, I.E. BETWEEN 3RD AND 7TH DAY OF LIFE. NEWBORNS WITH HIGH INITIAL TSH VALUES …
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The Effect of Hypothyroidism on Glucose Tolerance in Dogs
Background: Canine hypothyroidism is thought to cause abnormalities in glucose homeostasis, but the effect on glucose tolerance and insulin sensitivity has not been determined to date. Hypothesis/Objectives: The purpose of the study was to investigate whether hypothyroidism has an effect on glucose …
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Predictive modelling of external dose rate from radionuclide therapy patients following discharge from hospital
… thyroidectomy, followed by radiodine ablation in hypothyroid or euthyroid state. Several attempts were made to predict the external dose rate, however, there is a lack of accuracy in predictions from existing models of dose rate decay. Objectives: Published models were compared to actual patient …
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The effects of induced hypothyroidism on the glucocorticoid stress response in Japanese quail (Coturnix japonica)
… (normal) concentrations of plasma T4, and a hypothyroid state, in which birds have depleted thyroidal T4 content and decreased concentrations of plasma T4. Thyroid function was assessed by measuring plasma T4 concentrations, thyroidal T4 content, and thyroid gland mass. I took blood samples …
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Effects of hypothyroidism on pancreatic islet development and tissue insulin signalling pathways in the ovine fetus
… of the project was to elucidate the effects of hypothyroidism on the growth and development of the sheep fetus in late gestation. Specifically, the project investigated the extent to which the changes in fetal growth induced by thyroid hormone deficiency were mediated by changes in pancreatic …
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Effects of ammonium perchlorate exposure on the thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos and post hatch chicks
… thyroid function and that the consequent hypothyroidism would alter the expression of thyroid sensitive genes. Laying Japanese quail hens were treated with 2000 mg/l and 4000 mg/l ammonium perchlorate in drinking water. Eggs from these hens were incubated. Embryos, exposed to perchlorate …
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Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function
… (T4) clearance. This loss of T4 can lead to hypothyroidism. In this study, an assay was validated for measuring UDP-GT activity toward T4 in Japanese quail (Coturnix japonica). Then UDP-GT induction by Aroclor 1254 was evaluated in quail, and quail and mice were compared in their responses to …
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Some in vivo effects of triiodothyronine on purine nucleotide synthesis
… was investigated in sulfaguanidine-fed hypothyroid rats. To prevent the rapid destruction of nucleotides caused by anoxia and ischemia an apparatus was designed to maintain ether anesthesia while providing normal levels of oxygen. Liver samples were obtained from anesthetized rats by …
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Status of end organ damage in newly detected hypertension, hypertension in thyroid disorders and knowledge and awareness of hypertension among physicians and public
… selected thyroid dysfunctional status (hyper and hypothyroid) and established biomarkers [thyroid stimulating hormone (TSH) and thyroxine (T4)]; and BP components [specifically Systolic BP (SBP), Diastolic BP (DBP), and Mean Arterial Pressure (MAP), and uniquely SBP:DBP ratio]. We followed rigid …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… was explored. C57BL/6 and IIA+ mice were made hypothyroid over a 10-week period or treated with thyroid hormone (T3) for 5 weeks. There were no significant changes in PLA2G2A abundance in response to thyroid status. The hypothyroid IIA+ mice did not increase their energy expenditure even with …
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Preneoplastic hepatocyte hypothyroidism underlies hepatocellular carcinoma progression
… etiology-independent. They also suggest that a hypothyroid status of preneoplastic lesions may contribute to their progression to HCC.
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