Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"hypothalamic pituitary adrenal axis"”.
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Transcriptome analysis of the hypothalamic-pituitary-adrenal axis in the experimentally domesticated fox
… in activity of the hormonal stress response, or hypothalamic-pituitary-adrenal (HPA) axis, has been associated with different personality traits and coping styles in humans and animals, while its dysregulation has been implicated in psychological disorders. The molecular basis of HPA axis …
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The FitzHugh-Nagumo model dynamics with an application to the hypothalamic pituitary adrenal axis
… cortisol secretion, which is controlled by the hypothalamic pituitary adrenal axis (HPA). Existing mathematical models for cortisol secretion do not include the entire cortisol secretion process, from the neural firing of cortopin releasing hormone(CRH) in the hypothalamus to cortisol secretion …
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EARLY LIFE STRESS EXPOSURE AND HYPOTHALAMIC PITUITARY ADRENAL AXIS: FROM MECHANISMS TO PERIPHERAL BIOMARKERS OF VULNERABILITY
È noto come fattori ambientali, quali ad esempio l’esposizione ad eventi stressanti nel corso della vita, siano in grado di aumentare il rischio di sviluppare disturbi psichiatrici stress correlati che si caratterizzano per differenti entità ed età di insorgenza a seconda del momento e della …
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The activity and functioning of the hypothalamic-pituitary-adrenal axis of the red deer stag (cervus elaphus)
The activity and functioning of the HPA axis was investigated in red deer stags under basal and stress induced conditions. In order to overcome the confounding effects of stress inherent in standard methods of blood collection, a portable remote blood sampling device (“DracPac”) was developed and …
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Circadian activation of the hypothalamic-pituitary-adrenal axis may affect central, but not peripheral, effect of lithium in conditioned taste aversion learning in rats
Activation of the hypothalamic–pituitary–adrenal (HPA) axis has been implicated in conditioned taste aversion (CTA) learning induced by lithium chloride. This study investigated if circadian activation of the HPA axis affects the lithium-induced CTA formation. The pairing of conditioned stimulus …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… the fetus culminating in activation of the hypothalamic-pituitary adrenal axis of the baboon and the ontogenesis of rate-limiting steroidogenic enzymes culminating in <em>de novo</em> F secretion. Protein kinase A (PK-A) activity in the baboon fetal adrenal gland cytosolic fraction was …
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The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease
… and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. …
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Effects of periconceptional undernutrition and twinning on ovine pregnancy
… glucose disposal following a glucose challenge. Hypothalamic-pituitary-adrenal axis tests in these fetuses showed decreased pituitary adrenocorticotropin hormone response to direct stimulation but increased adrenal response to decreased cortisol negative feedback. Twin fetuses grew more slowly in …
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Understanding The Role Of Nutritional Stress In The Adult And Developing Zebra Finch
… the effects NS on females are still unclear. The hypothalamic-pituitary-adrenal axis (HPA) has been implicated in this process. However, evidence directly linking HPA functioning to the deficits due to NS have inconsistently shown elevations in CORT. Additionally, the effects of early NS on the …
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Stress And Social Relationships: The Role Of Corticosterone In The Formation And Maintenance Of Pair Bonds In The Monogamous Zebra Finch (taeniopygia Guttata)
… rodents, suggest that activation of the hypothalamic-pituitary-adrenal axis (HPA) in males increases attraction for females. Across species, females are understudied, but evidence from the prairie vole suggests HPA activation impairs formation of partner preference, the first step in …
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Translational Regulation in Excitatory Neurons Controls Stress Reactivity and the Antidepressant Response to Ketamine
… whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling, which phosphorylates 4E-Binding Protein 1 and 2 (4E-BPs) to promote synaptic …
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Reciprocal Relationships Between the Neuroendocrine System and Lymphoid Cells
… understood. Acute stressors activate both the hypothalamic-pituitary-adrenal axis and sympathomedullary system, which results in increased plasma concentrations of glucocorticoids and cathecholamines. Lymphoid cells possess receptors for both of these stress-related hormones, and activation of …
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The Effect of Increased Sleep on the Circadian Rhythm of Salivary Cortisol Concentrations
<p>Cortisol is a salivary marker for the hypothalamic-pituitary-adrenal axis (HPA) component of the stress response. The activity of the HPA demonstrates a circadian rhythm. It is well known that sleep deprivation increases cortisol concentrations. In this study, we looked at the effect of an …
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Unravelling the role of tryptophan metabolism in the microbiota-gut-brain axis: focus on the effects of stress and exercise
The involvement of the microbiota-gut-brain axis communication in brain function and behaviour has enabled a paradigm shift in neuroscience, neurogastroenterology and psychiatric research. Two key routes of this bidirectional communication are impaired in stress-related disorders: the …
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The Relationship of Level of Traumatic Exposure, Perceived Stress, and Resilience with Salivary Cortisol and Salivary Alpha-Amylase Diurnal Rhythm in Palestinian Children 10-12 Years Exposed to Chronic War Violence
… zone. Salivary cortisol, a surrogate marker of hypothalamic-pituitary-adrenal axis (HPA) activity, and salivary alpha-amylase, a surrogate marker of sympathetic nervous system (SNS), have been used to explore relationships of studies psychoneurobiological factors and processes related to stress. …
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A Preoptic Neurocircuit that Regulates Blood Glucose Homeostasis
… shift is executed via engagement of the hypothalamic-pituitary-adrenal axis, and impairment of this process via silencing of avPOA_Vglut2/PACAP neurons results in a loss of fasting glucose homeostasis. Taken together these results nominate torpor-associated avPOA_Vglut2/PACAP neurons as …
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Corticotropin-releasing factor and acute post-operative gut function in truamatic abdominal injury and elective abdominal surgery
… response driven by cytokine release and the hypothalamic-pituitary-adrenal axis. The response is activated under stress by corticotropin-releasing factor (CRF), the well-known 41 amino acid peptide neuro-hormone. Evidence from animal and human studies suggests that peripheral CRF is present …
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Obesity Related Perturbations On Cardiovascular, Immune And Endocrine Response To Active And Passive Stress
… between the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis when activated in response to passive stress. These results indicate that the presentation of an abnormal stress response may occur at different times based on the type of stress. In response to passive stress, …
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Brains, genes and environment of suicide attempters
… the relationship between suicidal intent and hypothalamic-pituitary-adrenal axis dysfunction in 78 suicide attempters with depression and adjustment disorder. In depressed patients, lower cortisol was associated with more serious suicide attempts. Paper III: We investigated how life-time …
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