Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"hyporesponsiveness"”.
-
Selbsttoleranz von NK-Zellen
… Funktionszustand wurde von anderen der Begriff hyporesponsiveness geprägt. Weiterhin wurde in drei Donoren eine Zellpopulation identifiziert, welche zwar einen inhibitorischen KIR exprimiert, der korrespondierende HLA-I-Ligand aber im Donor nicht vorhanden ist. Auch diese Zellen sind …
-
Hyporesponsive synovial fluid T cells in rheumatoid Arthritis
… T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T cells. The identity, origin and function of the proposed factor …
-
The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… might be responsible for the loss of vascular hyporesponsiveness in the presence of a potent vasoconstrictor, angiotensin II, in our model of prolonged hemorrhagic shock. The deleterious effect of NO is also shown in our combine model of prolonged hemorrhagic shock and fluid percussion injury. …
-
Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… NK cells (NK<sup>TROG+</sup>) and NK cell hyporesponsiveness. This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR (aCAR) against the cognate tumor antigen and an NK self-recognizing inhibitory CAR (iCAR) that transferred a “don't kill me” signal to NK …
-
Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… IL-1 is thought to promote chondrocyte hyporesponsiveness to IGF-I. To better understand how the anabolic (IGF-I) and catabolic (IL-1) stimuli are linked within articular cartilage, we examined the mechanisms by which IL-1 regulates the IGF-I signaling system of ACs. Equine chondrocytes …
-
Actions of Antimicrobial Peptides and Bacterial Components in Inflammation
… we confirmed by showing that M1 protein caused hyporesponsiveness to the vasoconstrictor, phenylephrine, in rat aorta. Bacterial compounds are able to activate Toll-like receptors generating an inflammatory response. Experiments using wild type and knockout mice revealed that M1 protein is able …
-
An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma
… compared to 19% of the HCs. Marker-specific hyporesponsiveness of platelets to agonist [adenosine diphosphate (ADP), thrombin receptor-activating peptide 6] stimulation in-vitro was observed, with significantly reduced surface levels of P-selectin in response to ADP in patients with MGUS. …
-
Compartmental responses of the respiratory tract to Staphylococcus aureus
… protein (tollip) has been demonstrated to induce hyporesponsiveness in the gastrointestinal tract in the presence of bacteria. So far, tollip has not been demonstrated in the respiratory tract. AIMS: To compare the responses of the upper and lower respiratory tract to TLR ligands, to characterise …
-
TLR1 I602S: trafficking dynamics and roles in resistance to mycobacterial infection
… receptor. The absence of surface TLR1 confers hyporesponsiveness of innate immune cells to TLR1 agonists whereby cells homozygous for TLR1 602S have deficient secretion of proinflammatory cytokines in response to extracellular ligands. It could be expected that individuals deficient in …
-
Investigation of T cell signalling events regulating immunity and tolerance in vivo
… is defined as a state of antigen-specific hyporesponsiveness, which is induced by exposure of T cells to antigen under sub-optimal activating conditions. For a T cell to become fully activated, and therefore productively primed, it must recognise its cognate antigen in the context of MHC …