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Showing 1 to 10 of 10 for “"hypoplastic left heart syndrome"”.
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Effects of GATA4-targeted compounds in hypertrophic models of hypoplastic left heart syndrome cardiomyocytes
Synnynnäiset sydänviat kehittyvät sydämen kehityksen aikana ja määritellään syntymähetkellä läsnä oleviksi sydämen rakenteellisiksi poikkeavuuksiksi, joista vasemman sydänpuoliskon vajaakehittyneisyysoireyhtymä (HLHS) edustaa harvinaista mutta hengenvaarallista alatyyppiä. HLHS:lle on ominaista …
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Lumped Parameter Model for a Self Powered Fontan Palliation of the Hypoplastic Left Heart Syndrome
<p>Out of all newborn infants with congenital heart disease (CHD), 8% have a single functioning ventricle. The Fontan surgical procedure, where the superior and inferior venous returns are connected directly to the pulmonary arteries to allow the single functioning ventricle to perfuse the systemic …
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Structural variant calling by assembly in whole human genomes: Applications in hypoplastic left heart syndrome
… the software Cortex-var for variant discovery in Hypoplastic Left Heart Syndrome (HLHS). This method circumvents many of the limitations of variants called from a reference alignment: unmapped reads will be included in a sample’s assembly, and variants up to thousands of nucleotides can be …
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Multi-Scale Fluid Flow Analysis of the Cardiovascular System
<p>The hypoplastic left heart syndrome (HLHS) is one of the rarest congenital heart diseases affecting infants. Out of 150 babies born, one baby suffers from congenital heart disease. Furthermore, nine percent out of those suffering from congenital heart disease specifically suffer from hypoplastic …
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Infant Heart Transplant: Perioperative Indicators of Neurocognitive Development
… in the United States are born with a congenital heart defect (Limperopoulos et al, 1999), the primary defect in 57% is hypoplastic left heart syndrome (Johnston, 1991). A fatal disease twenty years ago, survival has jumped from less than 5% to 91% of infants surviving their one-month birthday due …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… is dysregulated in Type 1 diabetic (T1D) and hypoplastic left heart syndrome (HLHS) patient hearts but the mechanisms responsible are unclear. Here, we provide evidence that in these patient’s hearts that dysregulation of the RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 contribute to …
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Evaluation of Recurrence Risks For Left-Sided Cardiac Lesions
<p>It is widely accepted that hypoplastic left heart syndrome (HLHS), aortic valve stenosis with or without bicuspid aortic valve (AS/BAV) and coarctation of the aorta (CoA) occur in families more commonly with each other than with any other congenital heart defect (CHD). Genetic counseling for …
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A Coupled CFD-Lumped Parameter Model of the Human Circulation: Elucidating the Hemodynamics of the Hybrid Norwood Palliative Treatment and Effects of the Reverse Blalock-Taussic Shunt Placement and Diameter
… new first stage procedure for neonates with Hypoplastic Left Heart Syndrome (HLHS), in which a sustainable univentricular circulation is established in a less invasive manner than with the standard procedure. A computational multiscale model of such HLHS circulation following the HN procedure …
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Full 3D Blood Velocity Mapping and Flow Quantification from Doppler Echocardiographic Images
… blood velocity and flow within the heart using 3D colour Doppler images. The<br/>principal goal of both methods was to overcome the main limitation of Doppler<br/>systems which is that the Doppler effect only measures one component of the velocity<br/>(parallel to the beam …
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Studies in right ventricular function: Employing the conductance catheter method for ventricular volume determination
… particularly after transplantation and during left ventricular (L V) assist device support. In the field of congenital heart disease, which has undergone rapid development in the last 20 years, many of the anatomical defects and corrective procedures directly involve the right ventricle. …