Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"hypoinsulinemia"”.
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Dietary manipulation causes childhood obesity-like characteristics in pigs
… fat deposition, and induced hyperglycemia, hypoinsulinemia, and low-density lipoprotein hypercholesterolemia; however, a 6 wk dietary intervention partially recovered a normal physiology. These data suggest pre-pubertal pigs fed HED are a viable animal model for studying childhood obesity.
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Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
… (Nidd/SJL, LOD score >8) for hyperglycemia with hypoinsulinemia was identified on the distal end of chromosome 4. This SJL-derived locus was responsible for a major part (60%) of the total prevalence of diabetes in the backcross population, apparently concealing the effects of other NZO-derived …
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Clinical and pathological characterization of a novel transgenic animal model of diabetes mellitus expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPR dn)
… and females showed severe hyperglycemia and hypoinsulinemia (p<0.05). In male transgenic animals, the fasted body weight was found to be lower than in age-matched male control mice. The daily food and water intake and the 24-hour urine volume were significantly higher in all transgenic …
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The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
… mice were glucose intolerant, resulting from hypoinsulinemia rather than insulin resistance. Pancreatic β-cells exhibited increased ER stress, including ER dilation and upregulation of the UPR. Proinsulin accumulated in the ER of β-cells from ERdj4 gene trap mice consistent with our previous …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… clinical studies suggest that both hyper- and hypoinsulinemia are associated with an increased risk for developing AD. Indeed, insulin signaling is altered in post-mortem brain tissue from AD patients and insulin and treatments known to enhance insulin signaling, can improve cognitive function. …