Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"hypoglycaemic"”.
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… has turned to looking at the use of oral hypoglycaemic agents (OHAs) for the treatment of GDM. There are two classes of OHAs used in pregnancy: biguanides (for example metformin) and sulphonylureas (for example glibenclamide, also known as glyburide). In the placenta a network of apical …
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The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
This thesis is concerned with the regulation of insulin receptors, with respect to receptor number, affinity and certain postreceptor effects of insulin action. The Aston obese hyperglycaemic (ob/ob) mouse was used as an animal model of obesity and type 2, NID diabetes mellitus. Hepatocyte insulin …
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Influence of patient-centred care and population health management approaches to improve adherence to oral hypoglycaemic agents in patients with type 2 diabetes mellitus in the borough of Hounslow (UK)
Type 2 diabetes mellitus (T2DM) is one of the top ten chronic diseases. It imposes a significant financial and disease burden worldwide. Lack of public awareness and non-adherence to treatment are the main factors contributing to difficulties in managing diabetes. In early 2016, during the …
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The molecular, hormonal and symptomatic responses to hypoglycaemia in mice
… clamps were used to create carefully controlled hypoglycaemic, euglycaemic and hyperglycaemic experimental interventions. Upon sequencing of the hypothalami, two thirds of nuclei were identified as neuronal. Across the dataset, there was relatively low expression of immediate early genes (IEGs), …
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Studies on the Role of Natural and Synthetic Sex Steroids in the Regulation of Carbohydrate Metabolism
… cell status. Natural sex steroids have a greater hypoglycaemic and hyperinsulinaemic influence than synthetic sex steroids. Combined steroid preparations elevate glycogen deposition, increase peripheral glucose utilisation and lower plasma glucose without elevating plasma insulin. Synthetic …
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The Influence of Ovarian Sex Steroids on Insulin Receptor Status in Mice
The hypoglycaemic action of exogenously administered insulin was significantly increased in mice at oestrus compared to mice at dioestrus, two stages of the oestrous cycle which represent high and low plasma concentrations of the ovarian sex steroids respectively. Unchanged insulin binding data …
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Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
… and to investigate novel ways to prevent hypoglycaemic episodes by detecting this early and with ease. This might ultimately translate into reduction in overall risk of hypoglycaemia occurrence in those with Type 1 Diabetes. I investigated potential factors that could predict persistent …
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Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action
… streptozotocin (STZ) diabetic rat model showing hypoglycaemic effects for the aqueous freeze dried extract. Messenger RNA and protein studies on C2C12 muscle cells revealed that the aqueous freeze dried extract and compound 1 enhanced insulin receptor, GLUT-4, glycogen synthase, pyruvate kinase …
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The effect of muscle glycogen status on control of substrate metabolism during exercise
… or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " …
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Effect of insulin and momordica charantia fruit juice extracts on glucose and ion transport in L6 rat muscle cell line
… and South America and it is believed to have hypoglycaemic effects in both human and experimental diabetes. The effects of insulin and M. cizarantia extracts A and B on 3H D-glucose and on N-methylamino-cz-isobutyric acid ( 14C Me-AIB) uptake, as well as their effects on cation transport were …
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Determination of the in vitro antidiabetic potential of a polyherbal commercial tea
… capacity, as well as in vitro toxicity and hypoglycaemic activity of a commercial ‘antidiabetic’ tea mixture (Diabetea) and its individual constituents: Achillea millefolium L. (Yarrow), Agathosma betulina Bartl. & Wendl. (Buchu), Salvia officinalis L. (Sage), Taraxacum officinalis L. …
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Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide
… with insulin or conventionally (diet ± oral hypoglycaemic agents). Beta cell function (glucagon-stimulated Cpeptide)and metabolic control (HbA1c) were followed for 36 months. LADA patients treated with insulin did not demonstrate better preservation of beta cell function but had a better …
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Metabolic and hormonal responses in the regulation of blood glucose levels in infants delivered by elective caesarean section
… and 1.8 mmol/l respectively. Three infants were hypoglycaemic with umbilical blood glucose levels of less than 2.6 mmol/l. The mean infant glucose and lactate levels were as expected for full term infants at 3.3 mmol/l and 2.2 mmol/l respectively. High mean levels of insulin and catechols were …
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Mathematical modelling of blood glucose regulation
… for the reduction in the likelihood of either hypoglycaemic or hyperglycaemic episodes. This may lead to recommendations for exercise plans which not only provide the greatest benefits for everyday health ant to assist with preventing the onset of diabetes but also to offer safer regimes for …
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Self-assembled peptide as a long-acting drug formulation
… and normalizes hyperglycaemia without risk of hypoglycaemic excursions [2]. However, native incretin hormones are quickly degraded by peptidases and renally excreted, which has so far impaired pharmaceutical exploitation of anorectic and glucose-homeostatic activities [3]. It is known that many …
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Animal-Computer Interaction: Designing Specialised Technology with Canine Workers
… seizure, have fallen, or have gone into a hypoglycaemic coma, it is down to their dog to take action to resolve the situation. Interactive technology can provide an assistance dog with the means to raise the alarm and summon help, but in order to enable them to independently and …
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Preparation and stability of organic nanocrystals. Experimental and molecular simulation studies.
… rather distinct, relatively insoluble drugs, the hypoglycaemic glibenclamide, the anti-inflammatory ibuprofen, and the anti-malarial artemisinin. The choice of crystal growth inhibitors/stabilizers was found to be critical and specific for each drug. The effect of the process variables, …
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Young-Onset Type 2 Diabetes in the Auckland Region - Clinical Outcomes and Healthcare Service Use in Comparison to Type 1 Diabetes
… an HbA1c >100mmol/mol were not dispensed any hypoglycaemic medication, 27% of those with cerebrovascular/cardiovascular/peripheral vascular disease were not dispensed a statin, and 30% with ACR >30mg/mmol were not dispensed an ACE inhibitor/angiotensin receptor blocker. Conclusions: A …
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A cost-utility and budget impact analysis of long-acting insulin analogues, (determir, glargine and degludec) for the treatment of adults with T1DM in South Africa
… two states representing nocturnal and daytime hypoglycaemic events respectively. Three scenarios were modelled in order to capture the variable rates of complications reported in the clinical evidence. Quality-Adjusted Life Years per patient year was the health outcome utilised. Costs were …
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Adherence to treatment by patients with type 2 diabetes mellitus at Monze Mission Hospital,Monze,Zambia
… levels as opposed to adhering to either oral hypoglycaemic drugs or insulin or both, to improve the management of type 2 Diabetes mellitus patients at Monze Mission Hospital. Adherence to type 2 Diabetes mellitus; Treatment; Patients.
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