Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"hypertrophic cardiomyopathy"”.
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Cardiac Vasoactive Peptides in Hypertrophic Cardiomyopathy of Cats
In conclusion, ANP and BNP are normally produced and stored in the atria. With HCM, significant peptide and mRNA expression of BNP is found in the ventricles, while protein and gene expression of ANP remains mainly in the atria. This pattern agrees with increases in plasma concentrations of both …
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Plasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathy
… [Nt-proANP] in plasma from cats with hypertrophic cardiomyopathy (HCM). Secondarily, we wished to evaluate the relationship between [Nt-proANP] and echocardiographic variables. Methods: Venous blood samples were obtained from seventeen cats with HCM and from nineteen healthy cats. …
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Haploinsufficiency of Cardiac Myosin Binding Protein-C in the Development of Hypertrophic Cardiomyopathy
… diseases including inherited cardiomyopathies. Hypertrophic Cardiomyopathy (HCM) is characterized by left ventricular wall thickening, diastolic dysfunction, and sarcomere disarray. Mutations in sarcomeric protein encoding genes have been established as causative for HCM.</p><p>The gene MYBPC3, …
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Modeling Action Potential Propagation During Hypertrophic Cardiomyopathy Through a Three-Dimensional Computational Model
<p>Hypertrophic cardiomyopathy (HCM) is the most common monogenic disorder and the leading cause of sudden arrhythmic death in children and young adults. It is typically asymptomatic and first manifests itself during cardiac arrest, making it a challenge to diagnose in advance. Computational models …
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease of the myocardium characterized by left ventricular hypertrophy and myofibrillar disarray. HCM is considered the most common cause of sudden cardiac death in young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have …
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Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
… of mitochondrial proteins contributes to the cardiomyopathy of FRDA. Methods: Conditional mouse models of FRDA cardiomyopathy with ablation of FXN (FXN KO) or FXN and SIRT3 (FXN/SIRT3 DKO) in the heart were compared to healthy controls. Hearts were evaluated using echocardiography, cardiac …
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Clinical and Molecular Overview of Hypertrophic Cardiomyopathy through JPH-2 Mutations and Presentation in Clinical Case Study
Hypertrophic Cardiomyopathy (HCM) is a disease which presents a distinct morphological change in cardiac tissue. Pathology of the disease widely ranges from being largely asymptomatic to the sudden onset of cardiac death. The disease's etiology stems from genetic mutations in various components of …
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Modeling the Effects of Mechanical Loading on Hypertrophic Cardiomyopathy Pathogenesis in Human Induced Pluripotent Stem Cell derived Micro Heart Muscle
… sarcomere apparatus of cardiomyocytes with hypertrophic cardiomyopathy, the most frequent cause of sudden cardiac death in the young. Currently, it is challenging to predict genotype-phenotype relationships in hypertrophic cardiomyopathy due to its incomplete disease penetrance. For example, …
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Effect of ivabradine, a novel I<sub>f</sub> current inhibitor, on dynamic obstruction of the left ventricular outflow tract in cats with preclinical hypertrophic cardiomyopathy: a single-dose study
A relevant subset of cats with hypertrophic cardiomyopathy (HCM) develop dynamic obstruction of the left ventricular outflow tract and mitral regurgitation secondary to hypertrophy of the left ventricle and systolic anterior motion (SAM) of the mitral valve. This leads to an increase in left …
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An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells
… such as congenital heart defects and hypertrophic cardiomyopathy are by far the most common sequelae in these infants, it is becoming increasingly apparent that a vulnerability towards malignant dysrhythmias is far more prevalent than generally reported in the literature. …
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Studies in cardiomyopathy: looking beyond the familiar
… characteristics, natural history and outcomes of cardiomyopathy amongst Africans. Familial aggregation of cardiomyopathy has not been studied systematically in an African setting. Further, it is not clear whether the various phenotypic expressions of cardiomyopathy represent disparate clinical …
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Metabolic alterations in patients with heart disease
… in therapies, chronic heart failure (CHF) and hypertrophic cardiomyopathy (HCM) are still associated with significant morbidity and mortality. These patients often have a significant limitation in their exercise capacity. We showed that there are widespread abnormalities of both systolic and …
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Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner
… Immunohistochemistry results showed signs of hypertrophic cardiomyopathy in TMAO-treated male hearts while female TMAO-treated hearts showed signs of dilated cardiomyopathy. Neither TMAO group showed signs of fibrosis. Overproduction of reactive oxygen species was only observed in male …
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To Phosphorylate or Not to Phosphorylate: The Role of Tropomyosin Phosphorylation in Cardiac Function and Disease
… mouse models of cardiac disease, including hypertrophic cardiomyopathy, dilated cardiomyopathy and myocardial infarction, indicating that Tm phosphorylation may play a role in the initiation, progression or modulation of cardiac disease. To determine the effect of loss of α-Tm …
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Multi-scale analysis of cardiac myoarchitecture
… induced myocardial infarction in the rat and hypertrophic cardiomyopathy associated with deletion of the gene for myosin binding protein C (cMyBP-C) in the mouse. Normal cardiac muscle fiber alignment within the ventricular wall was characterized by a series of helical tracts transitioning …
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Statistical foundations for precision medicine
… resources. I use the inherited heart disease hypertrophic cardiomyopathy (HCM) to illustrate these concepts. HCM has proven tractable to genomic sequencing, which guides risk stratification for family members and tailors therapy for some patients. However, these benefits carry risks. I show …
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Development of a Model System for Culturing Neonatal Rat Ventricular Myocytes in vitro to Monitor Integrin Activation in Response to Altered Contractile Force
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and remains the leading cause of sudden cardiac death (SCD) in young adults. Recent evidence links mutations within sarcomeric proteins to the HCM disease state. The interplay between the forces generated by the contractile apparatus …
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The Role of ECSIT in Mitochondrial Dysfunction Mediated Cardiomyopathy
… was identified in ECSIT which resulted in a hypertrophic cardiomyopathy phenotype in homozygous mutant animals. Further investigation revealed this phenotype to be a result of a loss of function in ECSIT’s role as a complex I assembly factor. Mitochondria from EcsitN209I/N209I hearts showed a …
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Precision Gene Editing for Muscle Diseases
… typically do not survive beyond their thirties. Hypertrophic cardiomyopathy (HCM), on the other hand, is a disease characterized by abnormal thickening of the heart muscle that can progress to heart failure and sudden cardiac death. It is often caused by a dominant-negative mutation in a …
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Ethnic differences in Cardiac Adaptation to Exercise
… (BCs; 54% female), and 52 black patients with hypertrophic cardiomyopathy (HCM). Any healthy subject exhibiting a mLVWT of >11mm (females) or >13mm (males), underwent comprehensive examination to look for phenotypic features of HCM. Male athletes were followed up for 69.7±29.6 months. Results …
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