Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"hypermutator"”.
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Development and road-testing of an inducible hypermutator strain of Pseudomonas aeruginosa
… (PA), the mutS gene is commonly mutated in hypermutator strains. MutS mutants display an elevated mutation rate (>100-fold, compared with the wild-type (WT)) and are often associated with the acquisition of antibiotic resistance in clinical PA isolates. In the current work, I construct a …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
… this doctoral work has also used a P. falciparum hypermutator parasite line to select for a piperaquine-resistant phenotype in vitro. Whole genome sequencing analysis (WGS) of the piperaquine-resistant lines obtained through these experiments has identified nonsynonymous SNPs in gene candidates …
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Germline mutation in rare disease
… on identifying and characterising germline hypermutators. Using sequencing data from the DDD and 100,000 Genomes Project datasets across ~20,000 parent-offspring trios, I identified fifteen children with an unusually large number of de novo mutations. Eight of these appear to be due to a …