Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"hypermutable"”.
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The Crosstalk Between DNA Mismatch Repair and Replication
… P286R polymerase ɛ (Polɛ-P286R) display a hypermutable phenotype usually seen in MMR-deficient cells, implying the blockage of MMR function by Polɛ-P286R. We show here that consistent with frequent misincorporation by Polɛ-P286R, elevated levels of MMR proteins were found in replicating …
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Selfish Mutations: the Genetic Basis of the Paternal Age Effect
… by the site-specific mutation rate caused by hypermutable CpG sites and the number of mutable alleles. The incidence of disease was explained satisfactorily only when a combination of positive selection and the site-specific mutation rate were included in the analysis.</p> <p>To provide …
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IN VITRO AND IN VIVO ACTIVITY OF DINB: ROLE IN MUCOID CONVERSION OF PSEUDOMONAS AERUGINOSA
… respiratory infection, where a high frequency of hypermutable mutants emerge, this ability of DinB to extend a mismatch at this site in mucA with a -1 frameshift could be a partial explanation for mucoid conversion in vivo. Having examined the activity of DinB, we have also shown that dinB is …
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Selektive Amplifikation, Klonierung und Sequenzierung eines hypermutablen Bereiches des Fanconi-Anämie-A (FANCA)-Gens aus Fibroblasten-Kulturen unterschiedlicher Passagen und Genotypen
… des Gens wurde herausgesucht, da dieser als hypermutabler Bereich in der Literatur beschrieben ist. In dieser Arbeit sollte untersucht werden, inwieweit Sequenzen des Exon 10 somatische Instabilität aufweisen. Hierzu wurden Fibroblasten eines Patienten und entsprechende Kontrollen in der …