Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"hyperlocomotion"”.
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Role of 5-ht2c receptor density on behaviour in mice
… improve mood, cause hyperphagia, obesity and hyperlocomotion. In order to investigate these hypotheses mouse models that either over- or under-expressed the 5-HT2C receptor were implemented. The 5-HT2C receptor expression pattern and levels were confirmed in all mouse lines. A behavioural …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… CIQ, attenuated NMDAR channel blocker-induced hyperlocomotion, working memory deficit as well as prepulse inhibition deficit in wildtype and heterozygous mice but not in GluN2C knockout mice. These results demonstrate that deficit in GluN2C-containing NMDARs leads to schizophrenia-like …
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Hippocampal Output to the Septum Regulates Locomotion and Exploration
… circuit is sufficient to acutely induce hyperlocomotion. Furthermore, we found that the DH-septum inhibitory pathway is critical for regulation of locomotion and exploratory behavior. Activation of the DH inhibitory output to the medial septum complex (MSc) decreased animals' distance …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… and morphine analgesia, tolerance, hyperalgesia, hyperlocomotion and reinforcement at adulthood. To do this we utilised a variety of different behavioural techniques such as the tail withdrawal assay, conditioned place preference (CPP), and locomotor analysis. We also investigated the influence of …
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The GluK4 Kainate Receptor Subunit Regulates Mood, Memory and Excitotoxic Neurodegeneration
… behavior, impaired sensorimotor gating, and hyperlocomotion relative to wild-type mice. GluK4 knockout mice also demonstrated impaired fear memory and spatial memory. Furthermore, my findings indicate that GluK4 is a key mediator of excitotoxic neurodegeneration: GluK4 knockout mice showed …
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Circadian desynchrony in the mouse: how does chronic exposure to rotating shift work-like patterns of light/dark affect circadian rhythms and neurobehavioural outcomes
… as animals displayed open field thigmotaxis and hyperlocomotion. To test the hypothesis that rotating light/dark cycle weakens the circadian pacemaker examination of the SCN was carried out with results indicating no aberrant upregulation of inflammatory markers and normal rhythmic expression of …
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The Role of Mu Opioid Receptors in the Behavioral Effects of Cocaine
Animal models have proven to be useful tools for modeling human neurochemical and behavioral responses to drugs of abuse, including cocaine. Cocaine is a psychomotor stimulant that facilitates monoaminergic neurotransmission by binding to transporters and inhibiting the reuptake of dopamine, …
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THE EFFECT OF MELATONIN IN PROTECTING AGAINST THE BEHAVIORAL CONSEQUENCES OF CHRONIC HYPOPERFUSION IN MIDDLE-AGED FEMALE RATS
Mild cognitive impairment (MCI) is a growing disorder among the elderly and can often go unnoticed for a significant portion of time. MCI is often preceded by vascular dysfunction and has the potential to cause irreversible damage to one’s cognitive ability. The neurocognitive consequences of MCI …