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Showing 1 to 18 of 18 for “"hypercoagulable"”.
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Coagulopathy in severe, isolated traumatic brain injury: A prevalence study
… by TEG. Of the total 109 TEGs, 59 samples were hypercoagulable, 10 were hypocoagulable and the remaining 40 normal. There was poor correlation between laboratory-based coagulation assessments and TEG. Conclusions: Contrary to what is reported in the literature, we found little evidence of a …
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Circulating progenitor cells in atrial fibrillation: Relationship to endothelial dysfunction, thrombogenesis and inflammation
… body of evidence to suggest that AF confers a hypercoagulable state. Disruption of endothelial homeostasis (damage vs. repair) is thought to be central to this process. The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently …
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Evaluation of hemostasis in hyperthyroid cats
… There is a significant likelihood of being in hypercoagulable state based on hyperthyroid state (P = 0.019) and serum T4 level is significantly associated with predicating hypercoagulability (P = 0.043). Hyperthyroidism is associated with significantly higher median fibrinogen concentration (P …
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Paediatric cardiac anaesthesia in sickle cell disease : a case series
… lead to vaso-occlusive injury, haemolysis and a hypercoagulable state. Sickling is precipitated by dehydration, hypoxia, hypothermia, acidosis and low flow states. Over time, multi-organ damage develops with significant morbidity and mortality. Paediatric patients with SCD and congenital heart …
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Real-world Pharmacological Anticoagulation and Clinical Outcomes of Venous Thromboembolism in Adults with Sickle Cell Disease
… of African descent. SCD is considered as a hypercoagulable state and venous thromboembolism (VTE) is a serious disease-specific complication. However, there have been limited real-world studies on VTE in SCD patients. This work aims to provide a comprehensive assessment of the risk factors …
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The impact of thromboelastography on patients with penetrating abdominal trauma requiring intensive care
… were: 42% normal, 42% hypocoagulable, 12% hypercoagulable and 4% mixed parameters. Fibrinolysis profiles were: 48% normal, 44% fibrinolysis shutdown and 8% hyperfibrinolysis. Mortality rate was 5% at 24 hours and 26% at 30 days, with no difference between the two groups. High grade …
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Coagulation in the HIV-positive pregnant patient: A thromboelastographic study
… including thrombocytopaenia. Pregnancy induces a hypercoagulable state. There are limited data on the coagulation status of women with term pregnancy and HIV receiving anti-retroviral medication. Regional anaesthesia is the technique of choice for caesarean section, and is contraindicated in a …
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Prevalence of acute deep vein thrombosis in HIV seropositive orthopaedic patients after major surgery at the University teaching hospital, Lusaka.
Hypercoagulable states and immobilization are known risk factors in the development of DVT after major orthopaedic surgery. However, the added effect of HIV to major orthopaedic surgery in developing DVT is unknown. In addition the benefits of D-dimer screening of patients after major surgery is …
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Prevalence of acute deep vein thrombosis in HIV seropositive orthopaedic patients after major surgery at the University teaching hospital, Lusaka.
Hypercoagulable states and immobilization are known risk factors in the development of DVT after major orthopaedic surgery. However, the added effect of HIV to major orthopaedic surgery in developing DVT is unknown. In addition the benefits of D-dimer screening of patients after major surgery is …
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A Prospective, Descriptive Study Evaluating The Evolution Of Covid-19 Associated Coagulopathy In Mechanically Ventilated, Critically-Ill Patients Using Standard Laboratory Coagulation Studies And Thromboelastography
… to ICU for mechanical ventilation were in a hypercoagulable state as demonstrated by TEG analysis. This state evolved over the 14-day observation period, emphasizing the importance of regular monitoring of coagulation parameters in these patients. A small group developed thrombotic …
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Identification of Multiple Levels of Trauma Induced Coagulopathy
… coagulopathy. The second was a development a hypercoagulable state that may be attributed to increased platelet function. The identification of these two competing coagulopathies in separate models highlights the inadequacies of the current plasma based clinical testing, and the need for …
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Spectrum of coagulation profiles in severely injured patients: A subgroup analysis from the FIRST ( Fluids in Resuscitation of Severe Trauma) trial
… guidelines in order to improve outcome. Hypercoagulable patients need to be recognised amongst the TIC patients as it results in different sequelae and impacts on clinical decision in the use of antifibrinolytic agents as compared to hypocoagulopathy.
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A Multi-Level Analysis of Major Health Challenges in the United States Using Data Analytics Approaches
… insert an indwelling urinary catheter, and hypercoagulable state were more important than generally known diagnoses such as diabetes and hypertension in the prediction of stroke 30-day readmission. Furthermore, machine learning-based models can be designed to provide a better predictive …
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An observational study to assess coagulation abnormalities in patients with elevated levels of urea and/or creatinine secondary to renal failure, presenting for renal biopsy – challenging conventional testing using visco-elastic testing
… secondary to renal failure. These range from hypercoagulable to hypocoagulable states due to a range of mechanisms well described in the literature. Conventional tests of coagulation such as INR and PTT do not adequately assess these disorders of coagulation. Thromboelastography (TEG®) has …
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Polypropylene and Polycarbonate containers have a varied effect on coagulation after haemodilution, as judged by TEG® in vitro
… only two devices which can reliably diagnose a hypercoagulable state. More will be mentioned on the TEG® later.
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ADAMTS13 Activity in Dogs with Chronic Enteropathies
Background: Chronic enteropathies (CE) predispose dogs to thromboembolic disease, but the underlying mechanisms are poorly understood. Humans with CE have decreased activity of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), a von Willebrand factor …
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Thromboelastography in the assessment of coagulation changes in peripheral vascular disease
… thus designating this group of patients as hypercoagulable.‘ Interestingly these patients are not deemed as such in clinical practice as the routine coagulation tests(RCTs) currently employed do not identify these abnormalities. The overall purpose of the research described in this thesis …
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Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies.
Abstract The last two decades has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis …