Global ETD Search
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Showing 1 to 13 of 13 for “"hyperandrogenism"”.
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Familial association of polycystic ovary syndrome (PCOS) in women attending the gynaecological endocrinology clinic at Groote Schuur Hospital
… menstrual disturbances, infertility and clinical hyperandrogenism. While the pathophysiology is not completely delineated, a strong familial association has been demonstrated, suggesting a genetic component. From January 2007 until February 2009, a total of 83 probands were recruited from the …
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Cardiometabolic aspects of polycystic ovary syndrome
… It is characterised by chronic anovulation and hyperandrogenism with the clinical manifestation of oligomenorrhoea, hirsutism and acne. A ten to twenty fold increased risk for type 2 diabetes in PCOS patients compared to weight matched female control subjects makes the syndrome of high …
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A Review to Critique the Literature on Polycystic Ovarian Syndrome Origins
… in women. PCOS has been associated with hyperandrogenism, insulin resistance, and hyperinsulinemia, suggesting an interaction between glucose metabolism and the ovary. There are differing criteria established to diagnose PCOS, which complicates its diagnosis. Gene studies have not led to …
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Mechanisms and Diagnosis of Thrombosis in PCOS
… of women in the US. PCOS is characterized by hyperandrogenism, chronic anovulation, and polycystic ovaries, and has been linked to increased risk for thrombosis, a leading cause of morbidity and mortality worldwide. However, the overall prevalence of thrombotic events and the mechanisms of …
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From bench to bedside, to track and field: The context of enhancement and its ethical relevance
… for Athletics Federation incorrectly consider hyperandrogenism an unfair advantage; and, the World Anti Doping Agency Code and its current revisions. Chapter 4 discusses enhancements in a democratic society, and addresses the neglected issue of justifying enhancement research (ER). I propose: …
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The Effects of Induced Polycystic Ovary Syndrome in NAG-1 Transgenic Mice
… women. PCOS is characterized by cystic ovaries, hyperandrogenism (heightened levels of male sex hormones), altered menstrual cycles and various metabolic dysfunctions. The metabolic symptoms associated with PCOS are difficult to treat, as they are a result of hormonal imbalances, rather than …
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Prevalence of PCOS diagnoses among women with menstrual irregularity in a diverse, multiethnic cohort
… menstrual irregularity, clinical or biochemical hyperandrogenism, and polycystic ovaries on ultrasound. An alternative is its diagnosis as one of exclusion due to similarities in presentation to other endocrine disorders. As a result, PCOS may often be misdiagnosed and mismanaged in the course of …
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In-vivo analysis of hypothalamic kisspeptin neuron activity patterns
… age, often presenting with subfertility and hyperandrogenism. Another hallmark of PCOS is increased LH pulsatility, suggesting potential dysfunction in the ARNKISS neuron pulse generator. I examined the activity of the pulse generator in two mouse models of PCOS. In the peripubertal androgen …
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A retrospective analysis of a community based weight loss programme in conjunction with group behavioural change sessions in women with polycystic ovary syndrome (PCOS).
… The major symptoms include ovarian disruption, hyperandrogenism, insulin resistance and polycystic ovaries. Interestingly, at least half of the women with PCOS are obese, with the excess weight playing a pathogenic role in the development and/or progress of the syndrome. In addition, PCOS is …
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EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM
… were no differences in the body fat composition. Hyperandrogenism and polycystic ovary phenotype was not accompanied by impaired glucose tolerance. Blocking the androgen action and estrogen synthesis indicated that reproductive phenotype was primarily due to excess estradiol. These studies …
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Ätiologie des funktionellen Hyperandrogenismus : endokrine Prädiktion von Genalterationen im CYP11a, CYP17, CYP21B,INS VNTR und LHß bei Hyperandrogenämie, Hyperinsulinämie oder Adipositas in prämenopausalen Patientinnen
Untersuchung spezifischer das Polycystische Ovar Sydrom betreffender Kandidatengene
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The role of progesterone receptor in hypothalamic kisspeptin neurons
… GnRH secretion. 2) follicular cysts developed by hyperandrogenism disappear when normal hormonal milieu restored. Thus through their steroid hormone receptors, progesterone and androgens may participate in the pathogenesis of female infertility. To test these hypotheses, the following specific …
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Pharmakokinetik und Biokonversion von Dehydroepiandrosteron nach Dexamethason-Vorbehandlung bei Frauen mit dem Syndrom der polyzystischen Ovarien
Die Hyperandrogenämie, Kardinalsymptom des polyzystischen Ovar-Syndroms (PCOS), tritt klinisch meistens in Form von Hirsutismus und/oder Zyklusstörungen mit chronischer Anovulation in Erscheinung. Ovar und Nebennierenrinde stellen die Hauptorte der weiblichen Androgen-Biosynthese dar und galten …