Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 55 for “"hyperalgesia"”.
-
Critical role of ROS in capsaicin-induced hyperalgesia
… were examined in mice. The capsaicin-induced hyperalgesia was used as a pain model since it has 2 distinctive pain components, primary and secondary hyperalgesia representing peripheral and central sensitization, respectively. Foot withdrawal frequencies in response to von Frey filament …
-
Study of alternative splicing events associated with hyperalgesia
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
-
Individual Differences in Secondary Hyperalgesia and Associated Neural Activity
… associated with chronic pain, and secondary hyperalgesia is a manifestation of central sensitization that reflects pain felt beyond the site of the injury (Nijs et al., 2021; Woolf, 2011). Secondary hyperalgesia is a stable physiological response, and previous research has identified group …
-
The effect of stimulus threat on experimentally induced secondary hyperalgesia
… uses a human surrogate model of secondary hyperalgesia that is a common feature of neuropathic pain. The value of experimentally inducing secondary hyperalgesia is that one can then test the influence of different pharmacological and nonpharmacological interventions. This may shed some …
-
Role of Cyclooxygenase Isoforms in Peripheral Neuropathic Pain Model
… injury includes severe mechanical allodynia and hyperalgesia in the region where the nerve innervates. The mechanism of the development of neuropathic pain was not yet well known and the solution for it was not also elucidated. The ligation of L5 spinal nerve entering the dorsal root ganglia …
-
Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
… medication overuse headache and opioid-induced hyperalgesia and allodynia. Despite the clinical impact of medication overuse headache the pathophysiology behind this disorder remains unclear and mechanism-based treatments are lacking. Although most acute headache treatments are alleged to cause …
-
Role of Rostromedial Tegmental Nucleus Afferents in Symptoms of Withdrawal from Chronic Ethanol Exposure
… the role of RMTg afferents in regulating hyperalgesia during acute withdrawal. I found that thermal hyperalgesia emerged early after the cessation of ethanol exposure and persisted into protracted withdrawal. cFos expression, a marker of recent neuronal activity, was significantly …
-
Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… a 4 week delay in the onset of tactile hyperalgesia that was independent of changes in blood glucose levels. Interestingly, forced-exercise induced protection against diabetes-induced tactile hyperalgesia was reversed in a dose dependent manner by the opioid antagonist, naloxone. …
-
Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… of opioids including analgesia, tolerance, hyperalgesia, locomotor function and reinforcement.<br/><br/>We generated FC in post-natal day (PD) 2-9 mice and investigated their nociception and morphine analgesia, tolerance, hyperalgesia, hyperlocomotion and reinforcement at adulthood. To do …
-
Spotting pain in the brain. Towards a useful animal model of pain
… changes in anaesthetized and conscious rats, hyperalgesia was induced by partially irradiating the hind paw of rats with UVB-light. Changes were monitored during 14 days after induction of hyperalgesia in conscious animals, whereas changes from anaesthetised animals were collected one day …
-
Transcriptiome analysis of a migraine model
… network between individuals with control and a hyperalgesia mouse model of chronic migraine. Chronic hyperalgesia was modeled using a nitroglycerin treatment. The transcriptome was characterized in the trigeminal ganglia and nucleus accumbens. Samples were sequenced using the Illumina HiSeq 4000 …
-
Medicinal cannabis for neuropathic pain
… showed the greatest efficacy in treating thermal hyperalgesia symptoms in CMT2A mice. This paralleled a clinically relevant dose of gabapentin (40mg/kg) in efficacy for improving thermal hyperalgesia, both as a single dose and in multiple doses across eight hours. Of the cannabinoids tested, high …
-
Comorbid opioid dependence and chronic pain: Clinical implications
… Is there evidence of opioid-induced hyperalgesia in humans?<br/><br/><b>Methods</b>:<br/><i style="">Primary data</i><br/>Participants were 467 treatment-seeking, opioid-dependent patients.<br/>Materials comprised standardised instruments – focusing on illicit substance use and mental …
-
Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… post-SCI which coincides with the emergence of hyperalgesia (mechanical, cold and thermal). Furthermore, anti-acrolein treatment hydalazine can reverse pain behavior. Consistent with this, acrolein is a known ligand that directly excites transient receptor potential ankyrin 1 receptor (TRPA1) in …
-
A tailored biocompatible neural interface for long term monitoring in neural networks
… somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia …
-
Synthesis and Evaluation of Dual-Acting Ligands for Mu Opioid And Neuropeptide FF Receptors
… and physiological tolerance that leads to hyperalgesia. Receptor desensitization due to excessive receptor activation by an agonist is but one source of physiological tolerance; it can also develop through the activation of homeostasis-regulating endogenous anti-opioid systems. One of these …
-
Evaluation of epidural morphine and incisional bupivacaine for analgesia following hemilaminectomy in the dog
… 3 cm from the surgical incision line (primary hyperalgesia) as well as on the lateral aspect of the stifle (secondary hyperalgesia). Assessments were carried out at fixed intervals over the 48 hour postoperative period. Significant differences were found between those groups treated with the …
-
CaMKIIbeta in Pain and Addiction
… the contribution of CaMKIIβ to opioid induced hyperalgesia (OIH) and showed that mice lacking CaMKIIβ never develop hyperalgesia after chronic opioid administration. I utilized this model to also study morphine antinociceptive tolerance and dependence, where I discovered that CaMKIIβ …
-
A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… mechanical allodynia and above- level hyperalgesia while on their treatment regimen. After a ten-day washout period of minocycline, the animals continued to demonstrate a significant reduction in below-level mechanical allodynia and above-level hyperalgesia. However, minocycline-treated …
-
Development of a mouse model for the study of osteoarthritis pain
… by monitoring weight bearing, mechanical hyperalgesia, cold allodynia, mechanical allodynia and vocalisation in response to knee compression for 12 weeks post-surgery. No significant weight bearing deficits were observed during the course of the study. Significant mechanical allodynia was …
Page 1 of 3