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Showing 1 to 4 of 4 for “"hydroxytropolone"”.
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Discovery and Development of a Three-Component Oxidopyrylium Cycloaddition and Its Application Towards alpha-Hydroxytropolone Synthesis
… endeavors made by our laboratory involving α-hydroxytropolones (αHTs).</p> <p>αHTs are a subclass of troponoid natural products that possess promising activity against a broad range of therapeutically significant targets. In order to gain access to these molecules, our laboratory utilizes an …
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Studies Toward a General Synthesis of Poly-Substituted Alpha-Hydroxytropolones
… 1: This chapter gives a brief history of α-hydroxytropolones, how they were discovered and unique properties of these substrates. Included is a background on the bioactivity of these substrates in cellular targets such as bacteria, fungi, parasites, tumors and toxicity, as well as their …
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Studies on the Synthesis, Function, and Properties of Troponoids
… of the magnesium activated fluorescence of α-hydroxytropolone. We demonstrate the tendency of troponoids to interact electronically with magnesium and calcium and potentially serve as a binding site for the development of novel sensors. We conclude with aqueous fluorescence titrations of our …
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Synthesis of Biologically Active Tropolones and Stereochemically Rich Compounds via Cross-Coupling Reactions
… synthesis and biological evaluations of alpha-hydroxytropolones (alpha-HTs). These seven-membered aromatic rings have three contiguous oxygen atoms that chelates to metals, thus, biologically having the ability to bind dinuclear metalloenzymes and promoting inhibition. Synthetic routes to …