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Showing 1 to 20 of 35 for “"hydroxysteroid dehydrogenase"”.
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Structure-function analysis of 11β-hydroxysteroid dehydrogenase
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11β-HSD1 has been identified as a novel target …
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Untersuchungen über Regulationsmechanismen der 11beta-Hydroxysteroid Dehydrogenase Typ 1
Die 11beta-HSD1 reguliert intrazellulär die Cortisolkonzentration durch Regeneration von Cortison z.B. aus dem Blutkreislauf, zu Cortisol. Daher stellt diese ein wichtiges Element in der Glucocorticoid-vermittelten Genregulation dar. Die 11beta-HSD1 wird ubiquitär exprimiert, auf hohem Niveau …
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Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… exist to promote immune privilege. 11beta hydroxysteroid dehydrogenase 1 (11β-HSD1) regulates cortisol locally in tissues and has already been localised to to some ocular surface and intraocular tissues. The aim of this thesis is to evaluate the functional role of 11β-HSD1 in the eye and …
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Placental 11b-hydroxysteroid dehydrogenase expression and birth weight in Hamilton County, TN
… fetal growth. Placental production of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol before passage into the fetus. This study tests the hypothesis that increased placental 11β-HSD2 expression has a positive correlation with an individualized birth weight centile. A …
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STUDIES ON THE SUBCELLULAR LOCALIZATION OF 3-BETA- HYDROXYSTEROID DEHYDROGENASE IN STEROIDOGENIC CELLS
… into various steroid intermediates by 3-β hydroxysteroid dehydrogenase/ Δ5-Δ4 isomerase (HSD3B), a process crucial for producing key hormones like progesterone and testosterone— deficiencies in HSD3B lead to disorders such as congenital adrenal hyperplasia and disrupted sexual development. …
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Obesity, 11β-hydroxysteroid dehydrogenase and metabolic changes in the pathogenesis of idiopathic intracranial hypertension
… with dysregulation of cortisol metabolism by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Additionally, 11β-HSD1 has a role in the regulation of intraocular pressure. This thesis hypothesised that 11β-HSD1 is involved in the aetiology of IIH and examined the roles of obesity, 11β-HSD1 and …
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The role of 11β-Hydroxysteroid Dehydrogenase type 1 and Hepatic Glucocorticoid Metabolism in the Metabolic Syndrome
… focus on the microsomal enzyme 11\(\beta\)-hydroxysteroid dehydrogenase type 1 (11\(\beta\)-HSD1) which activates cortisone to cortisol in vivo. Through a series of in vitro and detailed translational studies, this thesis attempts to investigate hepatic glucocorticoid metabolism with …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… In mineralocorticoid-target tissues, 11β- Hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates glucocorticoids, conferring aldosterone specificity upon the normally unselective MR. Recent evidence suggests that 11β-HSD2 may also afford protection of MR in the cells of the vasculature, …
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Estrogen Regulation of the Pregnant Baboon Placental 11β-Hydroxysteroid Dehydrogenase (11β-HSD)-Catalyzed Metabolism of Cortisol and Cortisone and Its Effect on the Development of the Fetal Hypothalamic-Pituitary-Adrenal Axis
… or CRH mRNA.</p> <p>Thirdly, since the 11β-hydroxysteroid dehydrogenase (11β-HSD)-catalyzed metabolism of maternal cortisol and cortisone by the placenta is an important component in the sequence of events regulating the function of the baboon fetal pituitary-adrenocortical axis, both baboon …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these …
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The impact of glucocorticoids upon the insulin sensitivity of skeletal muscle
… also highlighted the importance of 11\(\beta\)-hydroxysteroid dehydrogenase type 1 (11\(\beta\)-HSD1), which controls local GC availability, as a critical regulator of skeletal muscle insulin sensitivity, and have provided new insight into the insulin sensitizing actions of selective …
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The metabolism of cortisol in the human feto-placental unit
… Kinetic parameters of the human placental 11β-hydroxysteroid dehydrogenase system were assessed using a microsomal preparation in 50% glycerol buffer. The Michaelis constant for cortisol was 1.88 x 10-6M, in the presence of NADP, and 0.56 x 10-6M, in the presence of NAD. Vmax values varied with …
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Steroidogenic cell populations in follicles of the chicken ovary
… 2); and (3) to identify the site of 3$\beta$-hydroxysteroid dehydrogenase (3$\beta$-HSD) in small, preovulatory, and postovulatory follicles (Experiment 3). Follicles were obtained from regularly laying chickens 2 hours after oviposition of the first egg of a clutch. P450 steroidogenic enzymes …
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Ruolo dei neurosteroidi nella modulazione dopaminergica
… lyase (CYP17A1), 3α- and 3β-hydroxysteroid dehydrogenase (HSD), in Sprague-Dawley rats and we tested the drug like FIN in a reserpinized rat probability discounting task, a behavioral paradigm aimed at capturing critical behavioral aspect of gambling disorder, namely the …
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The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… kinase inhibitor 2A (p16INK4A), 11β-Hydroxysteroid dehydrogenase type 1 and 2 (11β-HSD1/HSD11B1 and 11β-HSD2/HSD11B2) mRNA expression increased in aged DFs. In DS cells, HAS2, Vimentin (VIM) ,PDPN, Lysosomal-associated membrane protein 1 (LAMP1), Sequestosome- 1 (P62) and Protease …
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Rapid social regulation of 3β-HSD activity in the songbird brain
… in regulating non-breeding aggression. 3β-hydroxysteroid dehydrogenase/Δ4-Δ5 isomerase (3β-HSD) catalyzes DHEA conversion to androstenedione (AE) and the cofactor NAD⁺ assists in this transformation. In this thesis, I asked whether brain 3β-HSD activity is regulated by social encounters in …
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Beyond membrane curvature: Clade 6 reticulons and their role within the plant endoplasmic reticulum
… contents in roots due to the presence of a 3β-hydroxysteroid dehydrogenase domain (3βHSD). In this body of work, the three members of clade 6 RTNs are characterised for the first time, revealing that RTN17, RTN18 and RTN21 localise to distinct punctate structures across the ER network. Analysis …
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Sarcopenia and cognitive ageing: investigating their interrelationship, biological correlates and the role of glucocorticoids
… technique to measure the activity of 11beta-hydroxysteroid dehydrogenase (11βHSD1) in the human brain in vivo. Results I consistently found a relationship between: some measures of brain structure and muscle size; markers of brain structure and muscle function, mostly grip strength and gait …
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BIOSYNTHESIS AND FUNCTION OF CARDIAC GLYCOSIDES IN THE CRUCIFER GENUS <i>ERYSIMUM</i>
… chain cleavage. Chapter 3 explores Ec3βHSD (a hydroxysteroid dehydrogenase), Ec3KSI (a ketosteroid isomerase), EcP5βR2 (a progesterone 5β-reductase), and EcDET2 (a steroid 5α-reductase), which are involved in oxidation and reduction of the steroid core and help to explain variation in cardiac …
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