Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"hydroxymethylation"”.
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The Role of Dna Methylation and Hydroxymethylation In Smooth Muscle Cell Phenotypic Change During Atherogenesis
… the presence and effects of DNA methylation and hydroxymethylation are not fully understood and their impact on vascular cell signal transduction and proliferation may prove to be critically important.</p> <p><strong>Hypothesis and Aims.</strong> The central hypothesis of this project is that an …
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Behavioural, genetic and epigenetic determinants of white matter pathology in a new mouse model of chronic cerebral hypoperfusion
… chronic cerebral hypoperfusion might impact on hydroxymethylation (a newly discovered epigenetic marker) in white matter, via perturbations in associated epigenetic pathways, namely methylation and/ or TETs. I. Effects of chronic cerebral hypoperfusion on white matter integrity and cognitive …
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… of the obesity phenotype. Further, DNA 5-hydroxymethylation (5-hmC) is one type of DNA methylation that is 10 times more abundant in the brain than peripheral tissues. However, to date, no study has been conducted examining whether DNA 5-hmC becomes altered in the brain following weight …
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Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer
… liver and the consequence of their differential hydroxymethylation in HCC.
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Global alterations of the epigenetic landscape define endometrial receptivity and provide a hallmark for endometriosis
… H3K27me3, as well as DNA methylation (5mC) and hydroxymethylation (5hmC) profiles by meDIP-seq and hmeDIP-seq, respectively, of endometrial biopsies from control and endometriosis patients. My data reveal considerable changes to the epigenome that occur during the transition from the …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… the Igf2 promoter, converting this region to a 5-hydroxymethylation (5-hmC) state that increase gene transcription. Remarkably, this manipulation led to improved memory retention in aged, but not middle-aged, rats. We next showed that baseline levels H2Bubi decrease with age in the hippocampus of …
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Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1
<p>Cytosine methylation of mitochondrial DNA (mtDNA) was first described several decades ago, but neither the mechanism generating this modification nor its functional significance was known. Because mitochondrial dysfunction is a hallmark characteristic of numerous human diseases, including …
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Characterising the role of TET2 in oestrogen receptor positive breast cancer
The activity of the transcription factor oestrogen receptor α (ER) drives tumour development and metastasis in ER positive (ER+) breast cancer. This subtype constitutes up to three-quarters of breast cancer cases, and treatments directly targeting ER are currently the standard of care. ER operates …